Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

65 questions · 67 findings · 5 reviews · Dementia and Cognitive Improvement

No studies found 7 · 10.4%GRADE not reported 0 · 0%Very low 4 · 6%Low 22 · 32.8%Moderate 23 · 34.3%High 11 · 16.4%

Donepezil 10 mg/day vs placebo

Clinical global impression: CIBIC‐Plus (Improvement) at 24 weeks 7‐point Likert scale · vascular dementia and other vascular cognitive impairments

Donepezil 10 mg showed no clear difference in clinical global impression: CIBIC‐Plus (Improvement) at 24 weeks… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Clinical global impression of change ‐ patient's self‐reported impression of memory change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ patient's self‐reported… (high certainty).

1 finding from 1 review

Intervention not reported

Clinical global impression of change ‐ patient's self‐reported impression of cognitive change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ patient's self‐reported… (high certainty).

1 finding from 1 review

Intervention not reported

Clinical global impression of change ‐ clinician's impression of memory change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ clinician's impression of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Clinical global impression of change ‐ clinician's impression of cognitive change · Multiple sclerosis

The intervention leads to higher clinical global impression of change ‐ clinician's impression of… (high certainty).

1 finding from 1 review