Donepezil 10 mg/day vs placebo: Adverse events (all adverse events) at 24 weeks
Donepezil 10 mg leads to higher adverse events (all adverse events) at 24 weeks compared with placebo (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Donepezil 10 mg vs placebo Adverse events (all adverse events) at 24 weeks · vascular dementia and other vascular cognitive impairments Donepezil 10 mg leads to higher adverse events (all adverse events) at 24 weeks compared with placebo (high certainty). Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network… (2021) · Cochrane Headline outcomes only | OR 1.95 [1.2, 3.15] | 2 studies · 813 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta‐analysis 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.