Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

202 questions · 207 findings · 17 reviews · Headline outcomes only

No studies found 23 · 11.1%GRADE not reported 32 · 15.5%Very low 61 · 29.5%Low 64 · 30.9%Moderate 18 · 8.7%High 9 · 4.3%

Benzodiazepines vs antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to any reason (overall acceptability of… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to adverse effects (overall tolerability… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ + haloperidol ‐ medium term As defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ + haloperidol ‐ medium term As… compared with same enzodiazepines (low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ lorazepam + risperidone vs lorazepam… compared with same enzodiazepines (low certainty).

1 finding from 1 review