Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

213 questions · 219 findings · 19 reviews

No studies found 25 · 11.4%GRADE not reported 33 · 15.1%Very low 70 · 32%Low 64 · 29.2%Moderate 18 · 8.2%High 9 · 4.1%

Benzodiazepines vs antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to any reason (overall acceptability of… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to adverse effects (overall tolerability… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ + haloperidol ‐ medium term As defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ + haloperidol ‐ medium term As… compared with same enzodiazepines (low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ lorazepam + risperidone vs lorazepam… compared with same enzodiazepines (low certainty).

1 finding from 1 review