Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐unadjusted compared with artesunate‐atovaquone‐proguanil (low certainty).
Atovaquone‐proguanil showed no clear difference in total failure [day 42 PCR‐adjusted compared with artesunate‐atovaquone‐proguanil (moderate certainty).
Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐unadjusted compared with artesunate‐atovaquone‐proguanil (moderate certainty).
Atovaquone‐proguanil showed no clear difference in early treatment failure compared with artesunate‐atovaquone‐proguanil (low certainty).
Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐adjusted compared with artesunate‐amodiaquine (low certainty).
Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐unadjusted compared with artesunate‐amodiaquine (low certainty).
Atovaquone‐proguanil showed no clear difference in early treatment failure compared with artesunate‐amodiaquine (low certainty).
Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐adjusted compared with artesunate‐mefloquine (high certainty).
Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐unadjusted compared with artesunate‐mefloquine (low certainty).
Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐adjusted compared with artesunate‐atovaquone‐proguanil (low certainty).
The intervention leads to lower death (high certainty).
The intervention leads to lower hypoglycaemia episodes (high certainty).
The intervention showed no clear difference in neurological sequelae at day 28 (moderate certainty).
The intervention probably leads to higher neurological sequelae at discharge (moderate certainty).
The intervention leads to lower hypoglycaemia episodes (high certainty).
The intervention leads to lower death (high certainty).
The review found no eligible studies for this question.
The intervention showed no clear difference in neurological sequelae at discharge (moderate certainty).