Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

106 questions · 122 findings · 17 reviews

No studies found 23 · 18.9%GRADE not reported 5 · 4.1%Very low 28 · 23%Low 37 · 30.3%Moderate 28 · 23%High 1 · 0.8%

Adjunctive antioxidants for schizophrenia vs placebo

Adverse effects: 1. Serious (any time point) ‐ any serious adverse effect Various methods · patients with schizophrenia

Adjunctive antioxidants for schizophrenia showed no clear difference in adverse effects: 1. Serious (any time point) ‐ any serious adverse… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Participant-reported resumption of normal eating, chewing and speech · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Intolerance to spicy food (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Antioxidants (lycopene, curcumin, Oxitard) led to lower intolerance to spicy food (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Antioxidants (lycopene, curcumin, Oxitard) probably leads to lower burning sensation (VAS 0-100) compared with placebo or no active treatment (moderate certainty).

3 findings from 1 review

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in maximal mouth opening (interincisal distance) compared with placebo or no active treatment (low certainty).

3 findings from 1 review

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review