Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

122 questions · 124 findings · 13 reviews · Kidney and Transplant

No studies found 19 · 15.3%GRADE not reported 0 · 0%Very low 46 · 37.1%Low 38 · 30.6%Moderate 21 · 16.9%High 0 · 0%

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Cure: short‐term success · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics plus antibiotic lock solutions plus tissue… changes cure: short‐term success compared with systemic antibiotics plus antibiotic lock solutions plus heparin (very low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Cure: long‐term success · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics plus antibiotic lock solutions plus tissue… changes cure: long‐term success compared with systemic antibiotics plus antibiotic lock solutions plus heparin (very low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Stenosis or thrombosis of vascular access site after catheter removal · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Development of antibiotic resistance · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Endoscopic injection treatment vs antibiotics alone

Febrile UTI by 1 to 2 years: endoscopic correction + antibiotics versus antibiotics alone · primary VUR

Endoscopic injection treatment showed no clear difference in febrile UTI by 1 to 2 years: endoscopic correction + antibiotics… compared with antibiotics alone (low certainty).

1 finding from 1 review

Endoscopic injection treatment vs antibiotics alone

Total new and progressive Renal parenchymal abnormalities on DMSA scan at 1 to 2 years: endoscopic correction + antibiotics versus antibiotics alone (unit of analysis: children) · primary VUR

Endoscopic injection treatment showed no clear difference in total new and progressive Renal parenchymal abnormalities on DMSA… compared with antibiotics alone (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Peritonitis · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Catheter removal or replacement · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in catheter removal or replacement (number of patients) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Number of participants with symptomatic UTI · primary VUR

Antibiotic prophylaxis showed no clear difference in symptomatic UTI by 1 to 2 years: antibiotics versus no prophylaxis compared with surveillance or no treatment (low certainty).

2 findings from 1 review