Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

98 questions · 101 findings · 24 reviews · Headline outcomes only

No studies found 16 · 15.8%GRADE not reported 8 · 7.9%Very low 42 · 41.6%Low 20 · 19.8%Moderate 14 · 13.9%High 1 · 1%

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ shallow anterior chamber ‐ primary trabeculectomy · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil showed no clear difference in complications ‐ shallow anterior chamber ‐ primary trabeculectomy compared with control (low certainty).

1 finding from 1 review

Intervention not reported

complications shallow anterior chamber occurring within 12 months · People undergoing trabeculectomy surgery with glaucoma

The intervention showed no clear difference in complications shallow anterior chamber occurring within 12 months (low certainty).

1 finding from 1 review

Immobilisation in external rotation vs immobilisation

Re‐dislocation · patients undergoing conservative management after closed reduction of traumatic anterior dislocation of the shoulder

It is very uncertain whether immobilisation in external rotation changes re‐dislocation compared with immobilisation (very low certainty).

1 finding from 1 review

Immobilisation in external rotation vs immobilisation

Any instability: re‐dislocation or subluxation, composite outcome · patients undergoing conservative management after closed reduction of traumatic anterior dislocation of the shoulder

It is very uncertain whether immobilisation in external rotation changes any instability: re‐dislocation or subluxation, composite outcome compared with immobilisation (very low certainty).

1 finding from 1 review

Intervention not reported

Subjective knee score ‐ KOOS‐4 score (mean score of 4 components) at 2 years: score from 0 (extreme symptoms) to 100 (no symptoms) · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)
1 finding from 1 review

Intervention not reported

Treatment failure (graft rupture or ACL reconstruction) at 2 years5 · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention may leads to lower treatment failure (graft rupture or ACL reconstruction) at 2 years5 (low certainty).

1 finding from 1 review

Intervention not reported

Treatment failure (meniscal surgery) at 5 years5,7 · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention showed no clear difference in treatment failure (meniscal surgery) at 5 years5,7 (low certainty).

1 finding from 1 review

Intervention not reported

General health‐related quality of life: SF‐36 physical component score (range 0 to 100; higher score = better health state) at 2 years · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)
1 finding from 1 review

Intervention not reported

Return to activity or level of sport at 2 years · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention showed no clear difference in return to activity or level of sport at 2 years (low certainty).

1 finding from 1 review