Findings

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Evidence found and GRADE certainty

47 questions · 47 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 10.6%Low 14 · 29.8%Moderate 26 · 55.3%High 2 · 4.3%

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower HIV Transmission or Death at 24 months among those uninfected at birth compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Mothers with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… may leads to higher mothers with Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission at 12 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers may leads to lower HIV transmission at 12 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or Death at 6 months among those whose HIV diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission or Death at 6 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers probably leads to lower HIV transmission or Death at 12 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (moderate certainty).

1 finding from 1 review