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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings ‐ Ciklavit® vs placebo Frequency of severe complications of SCD · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: insulin vs placebo HbA1c · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | 1 study · 39 participants | Very low |
Summary of findings: repaglinide vs placebo Hypoglycemia: number of episodes · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | RR 12.52 [0.74, 211.2] | 1 study · 51 participants | Very low |
Summary of findings: repaglinide vs insulin HbA1c (%) change from baseline · children over 12 and adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | MD 0.3 | 1 study · 67 participants | High |
Summary of findings: repaglinide vs insulin FEV1 % predicted change from baseline · children over 12 and adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | 2 studies · 112 participants | Moderate |
Summary of findings: repaglinide vs insulin FVC % predicted change from baseline · children over 12 and adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | 2 studies · 112 participants | Moderate |
Summary of findings: repaglinide vs insulin BMI (kg/m²) change from baseline · children over 12 and adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | MD 0.24 | 1 study · 45 participants | Low |
Summary of findings: repaglinide vs insulin Hypoglycemia number of episodes · children over 12 and adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | RR 1.38 [0.48, 4.01] | 2 studies · 56 participants | Low |
Summary of findings: NPH insulin vs glargine HbA1c · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: NPH insulin vs glargine FEV1 % predicted · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: NPH insulin vs glargine FVC % predicted · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: NPH insulin vs glargine BMI kg/m² · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: insulin vs placebo FEV1 % predicted: change from baseline · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | MD 1.2 | 1 study · 39 participants | Low |
Summary of findings: NPH insulin vs glargine Hypoglycemia mean number of events per participant · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | 1 study · 19 participants | Very low |
Summary of findings: insulin vs placebo FVC % predicted: change from baseline · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | MD 0.6 | 1 study · 39 participants | Low |
Summary of findings: insulin vs placebo BMI(kg/m²): change from baseline · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | MD 0.41 | 1 study · 39 participants | Low |
Summary of findings: insulin vs placebo Hypoglycemia: number of episodes · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | RR 9.23 [0.53, 159.14] | 1 study · 55 participants | Low |
Summary of findings: repaglinide vs placebo HbA1c · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | 1 study · 38 participants | Very low |
Summary of findings: repaglinide vs placebo FEV1 % predicted; change from baseline · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | MD 1.7 | 1 study · 38 participants | Low |
Summary of findings: repaglinide vs placebo FVC % predicted: change from baseline · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | 1 study · 38 participants | Low |
Summary of findings: repaglinide vs placebo BMI (kg/m²): change from baseline · adults with CFRD Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | MD 0.17 | 1 study · 38 participants | Low |
Summary of findings: respiratory muscle training vs control FEV1 % predicted · adults and children with cystic fibrosis Respiratory muscle training for cystic fibrosis (2020) · Cochrane | no estimate extracted | 4 studies · 83 participants | Very low |
Summary of findings: respiratory muscle training vs control FVC: % predicted · adults and children with cystic fibrosis Respiratory muscle training for cystic fibrosis (2020) · Cochrane | no estimate extracted | 3 studies · 72 participants | Very low |
Summary of findings: respiratory muscle training vs control Exercise capacity: VO2max (mL/kg/min) · adults and children with cystic fibrosis Respiratory muscle training for cystic fibrosis (2020) · Cochrane | no estimate extracted | 3 studies · 54 participants | Very low |
Summary of findings: respiratory muscle training vs control HRQoL: total score · adults and children with cystic fibrosis Respiratory muscle training for cystic fibrosis (2020) · Cochrane | no estimate extracted | 3 studies · 69 participants | Very low |
Summary of findings: respiratory muscle training vs control Respiratory muscle function: maximal inspiratory pressure (PImax) · adults and children with cystic fibrosis Respiratory muscle training for cystic fibrosis (2020) · Cochrane | no estimate extracted | 4 studies · 87 participants | Very low |
Summary of findings: respiratory muscle training vs control Respiratory muscle function: inspiratory capacity · adults and children with cystic fibrosis Respiratory muscle training for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Oscillating devices vs PEP FEV1: % predicted · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 15 studies · 510 participants | Very low |
Oscillating devices vs breathing techniques FVC · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 8 studies · 181 participants | Low |
Oscillating devices vs breathing techniques Sputum: volume (g) · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 14 participants | Low |
Oscillating devices vs breathing techniques Sputum: weight (dry or wet) (g) · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 6 studies · 114 participants | Low |
Oscillating devices vs breathing techniques Frequency of exacerbationsb · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Oscillating devices vs breathing techniques Participant‐reported satisfaction with treatment intervention · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 6 studies · 114 participants | Low |
Oscillating devices vs conventional physiotherapy FEV1: % predicted · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 10 studies · 363 participants | Very low |
Oscillating devices vs conventional physiotherapy FEF25-75: % predicted · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 8 studies · 319 participants | Very low |
Oscillating devices vs conventional physiotherapy FVC · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 7 studies · 268 participants | Very low |
Oscillating devices vs conventional physiotherapy Sputum: volume · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 17 participants | Low |
Oscillating devices vs conventional physiotherapy Sputum: weight (dry or wet) · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 8 studies · 188 participants | Very low |
Oscillating devices vs PEP FEF25-75 : % predicted · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 9 studies · 355 participants | Very low |
Oscillating devices vs conventional physiotherapy Frequency of exacerbationsb · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 4 studies · 262 participants | Very low |
Oscillating devices vs conventional physiotherapy Participant‐reported satisfaction with treatment intervention · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 9 studies · 345 participants | Very low |
Oscillating devices vs different oscillating devices FEV1 · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 6 studies · 320 participants | Very low |
Oscillating devices vs different oscillating devices FEF25-75 · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 3 studies · 211 participants | Very low |
Oscillating devices vs different oscillating devices FVC · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 5 studies · 290 participants | Very low |
Oscillating devices vs different oscillating devices Sputum: volume · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Oscillating devices vs different oscillating devices Sputum: weight (dry or wet) Folllow‐up: 6 days · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 24 participants | Low |
Oscillating devices vs different oscillating devices Frequency of exacerbationsb · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 16 participants | Very low |
Oscillating devices vs different oscillating devices Participant‐reported satisfaction with treatment intervention · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 5 studies · 265 participants | Very low |
Oscillating devices vs PEP FVC · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 9 studies · 362 participants | Very low |
Oscillating devices vs PEP Sputum: volume (mL) · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 23 participants | Low |