Findings

What do systematic reviews say?

563 questions · 568 findings · 104 reviews · Headline outcomes only

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No studies found 53 · 9.3%GRADE not reported 26 · 4.6%Very low 85 · 15%Low 214 · 37.7%Moderate 151 · 26.6%High 39 · 6.9%

Inhaled steroids vs systemic steroids

Death or moderate/severe disability at 7 years · Neonates with developing BPD

Inhaled steroids showed no clear difference in death or moderate/severe disability at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
RR 1.01 [0.65, 1.58]
1 study · 107 participants
Moderate

Inhaled steroids vs systemic steroids

Systolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids showed no clear difference in systolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
RR 0.55 [0.25, 1.23]
1 study · 70 participants
Moderate

Oral betamimetic vs placebo

Prelabour rupture of membranes · women with a twin pregnancy

Oral betamimetic showed no clear difference in prelabour rupture of membranes compared with placebo (low certainty).

1 finding from 1 review

Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy 2015 · Cochrane Headline outcomes only
RR 1.42 [0.42, 4.82]
1 study · 144 participants
Low