Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,733 questions · 1,794 findings · 326 reviews · Headline outcomes only

No studies found 243 · 13.5%GRADE not reported 96 · 5.4%Very low 597 · 33.3%Low 506 · 28.2%Moderate 303 · 16.9%High 49 · 2.7%

Acupuncture vs sham

Quality of life (either short or long term) ‐ not measured · symptomatic gastroparesis

The review found no eligible studies for this question.

1 finding from 1 review

Open surgery by transverse incision of the skin in the distal palmar crease vs open surgery

Pain (short‐term) Not measured · patients with trigger finger

The review found no eligible studies for this question.

3 findings from 1 review

Noradrenaline reuptake inhibitors vs placebo

Mental state: significant response or improvement in negative symptoms (PANSS negative subscale, high = worse) ‐ short term (12 weeks) · adults with schizophrenia

It is very uncertain whether noradrenaline reuptake inhibitors changes mental state: significant response or improvement in negative… compared with placebo (very low certainty).

1 finding from 1 review

Noradrenaline reuptake inhibitors vs placebo

Clinical global response: significant response or improvement in global status (CGI‐S, high = worse) ‐ short term (4 weeks) · adults with schizophrenia

It is very uncertain whether noradrenaline reuptake inhibitors changes clinical global response: significant response or improvement in… compared with placebo (very low certainty).

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Depressive symptoms · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care showed no clear difference in self‐reported depressive symptoms short term (up to 6 months) ‐ BDI… compared with usual care alone (moderate certainty).

4 findings from 1 review
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Psychotherapy as an adjunct to usual care vs usual care

> 50% reduction in depressive symptoms · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in depressive symptoms from baseline) short… compared with usual care alone (low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical performance · critically ill, mechanically ventilated adults
2 findings from 1 review