Acceptability ‐ total dropouts · adults with Major Depressive Disorder
Ketamine showed no clear difference in acceptability: total dropouts№ of participants: 72(1 RCT) compared with midazolam (low certainty).
1 finding from 1 review
OR 0.33 [0.05, 2.09]
Studies not reported
Low
Relapse · participants with depressive or anxiety disorders
It is very uncertain whether discontinuation by "tapering" changes relapse (as defined by study authors) (HR) compared with continuation (or usual care) (very low certainty).
1 finding from 1 review
Withdrawal symptoms · participants with depressive or anxiety disorders
1 finding from 1 review
Adverse events · participants with depressive or anxiety disorders
It is very uncertain whether discontinuation by "tapering" changes adverse events compared with continuation (or usual care) (very low certainty).
1 finding from 1 review
Anxiety · participants with depressive or anxiety disorders
1 finding from 1 review
Quality of life · participants with depressive or anxiety disorders
1 finding from 1 review
Social and occupational functioning · participants with depressive or anxiety disorders
1 finding from 1 review
Risk of relapse (as defined by study authors) (HR) · participants with long‐term antidepressants for depressive disorders
Discontinuation with high‐intensity psychological interventions showed no clear difference in risk of relapse (as defined by study authors) (HR) compared with continuation (low certainty).
1 finding from 1 review
Withdrawal symptoms · participants with long‐term antidepressants for depressive disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · participants with long‐term antidepressants for depressive disorders
1 finding from 1 review
Anxiety · participants with long‐term antidepressants for depressive disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · participants with long‐term antidepressants for depressive disorders
1 finding from 1 review
Social and occupational functioning · participants with long‐term antidepressants for depressive disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Successful discontinuation rate · participants with depressive or anxiety disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
fluoxetine:desvenlafaxine · children and/or adolescents with depression
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Intervention not reported
citalopram:paroxetine · children and/or adolescents with depression
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
mirtazapine:vortioxetine · children and/or adolescents with depression
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
paroxetine:sertraline · children and/or adolescents with depression
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
paroxetine:venlafaxine · children and/or adolescents with depression
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
vilazodone:paroxetine · children and/or adolescents with depression
1 finding from 1 review
no estimate extracted
Studies not reported
Very low