What do systematic reviews say?

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 226 participants
  Moderate

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 147 participants
  Moderate

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 79 participants
  Moderate

NSAIDs vs placebo

Summary of findings: non‐steroidal anti‐inflammatory drugs showed no clear difference in proportion with at least 1 hospital admission compared with placebo (moderate certainty).

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  OR 0.61 [0.37, 1.01]
  4 studies · 286 participants
  Moderate

Summary of findings ‐ PEP vs PDPV

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 155 participants
  Low

Summary of findings ‐ PEP vs oscillating PEP

The review found no eligible studies for this question.

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ PEP vs oscillating PEP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 68 participants
  Moderate

Summary of findings ‐ PEP vs oscillating PEP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 75 participants
  Low

Summary of findings ‐ PEP vs oscillating PEP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Low

Summary of findings ‐ PEP vs oscillating PEP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  22 participants
  Low

Summary of findings ‐ PEP vs HFCWO

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 174 participants
  Low

Summary of findings ‐ PEP vs HFCWO

Summary of findings ‐ PEP leads to lower number of respiratory exacerbations compared with HFCWO (high certainty).

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  RR 0.73 [0.55, 0.95]
  1 study · 107 participants
  High

Summary of findings ‐ PEP vs HFCWO

The review found no eligible studies for this question.

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ PEP vs HFCWO

The review found no eligible studies for this question.

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ PEP vs HFCWO

The review found no eligible studies for this question.

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ PEP vs PDPV

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 66 participants
  Low

Summary of findings ‐ PEP vs HFCWO

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  15 participants
  Very low

Summary of findings ‐ PEP vs HFCWO

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 107 participants
  High

Summary of findings ‐ PEP vs BiPAP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 52 participants
  Low

Summary of findings ‐ PEP vs BiPAP

The review found no eligible studies for this question.

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found