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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Aggressive vs conservative blood transfusion Quality of life · people with SCD Preoperative blood transfusions for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Preoperative blood transfusion vs no transfusion Mortality · people with SCD Preoperative blood transfusions for sickle cell disease (2020) · Cochrane | no estimate extracted | 2 studies · 434 participants | Ungraded |
Preoperative blood transfusion vs no transfusion Serious complications related to SCD ‐ ACS · people with SCD Preoperative blood transfusions for sickle cell disease (2020) · Cochrane | no estimate extracted | 2 studies · 434 participants | Very low |
Silboesterol vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Reduction in frequency of priapism · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 23 participants | Very low |
Etilefrine vs placebo Immediate side effects of treatment (palpitations) · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | RR 1.64 [0.62, 4.3] | 1 study · 23 participants | Very low |
Etilefrine vs placebo Immediate side effects of treatment (tachycardia) · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | RR 2.18 [0.71, 6.68] | 1 study · 23 participants | Very low |
Etilefrine vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Reduction in stuttering priapism · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | RR 2.92 [0.73, 11.7] | 1 study · 7 participants | Very low |
Ephedrine vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Ephedrine vs placebo Reduction in frequency of priapism · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 24 participants | Very low |
Ephedrine vs placebo Immediate side effects of treatment with 30 mg ephedrine (palpitations) · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | RR 1 [0.32, 3.1] | 1 study · 24 participants | Very low |
Ephedrine vs placebo Immediate side effects of treatment with 30 mg ephedrine (tachycardia) · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | RR 0.67 [0.13, 3.3] | 1 study · 24 participants | Very low |
Ephedrine vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Ephedrine vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Ephedrine vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Immediate side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Reduction in frequency of priapism · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | RR 0.58 [0.07, 4.95] | 1 study · 13 participants | Low |
Sildenafil vs placebo Immediate side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 13 participants | Low |
Summary of findings ‐ Niprisan® vs placebo Frequency, severity or duration of painful crises: frequency of mild, moderate and severe pain episodes · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 70 participants | Low |
Summary of findings ‐ Ciklavit® vs placebo Frequency of hospital admissions from severe complications of SCD · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Ciklavit® vs placebo Any adverse events including hepatic and renal toxicity · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 87 participants | Low |
Summary of findings ‐ Ciklavit® vs placebo Frequency of blood transfusion · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Ciklavit® vs placebo Level of anaemia: packed cell volume · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 87 participants | Low |
Summary of findings ‐ Ciklavit® vs placebo Quality of life measures · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Pfaffia paniculata vs placebo Frequency, severity or duration of painful crises · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Pfaffia paniculata vs placebo Frequency of severe complications of SCD · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Pfaffia paniculata vs placebo Frequency of hospital admissions from severe complications of SCD · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Pfaffia paniculata vs placebo Any adverse events including hepatic and renal toxicity · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Pfaffia paniculata vs placebo Frequency of blood transfusion · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Niprisan® vs placebo Frequency of severe complications of SCD · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 70 participants | Low |
Summary of findings ‐ Pfaffia paniculata vs placebo Level of anaemia: packed cell volume · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Pfaffia paniculata vs placebo Quality of life measures · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Pfaffia paniculata vs placebo Number of sickle cells, peripheral erythroblasts and reticulocytes · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Niprisan® vs placebo Frequency of hospital admissions from severe complications of SCD · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 70 participants | Low |
Summary of findings ‐ Niprisan® vs placebo Any adverse events including hepatic and renal toxicity · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 80 participants | Low |
Summary of findings ‐ Niprisan® vs placebo Frequency of blood transfusion · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Niprisan® vs placebo Level of anaemia: change in level of haemoglobin (g/dL) · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 52 participants | Low |
Summary of findings ‐ Niprisan® vs placebo Quality of life measures: self‐reported health, absence from work or school · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 70 participants | Very low |
Summary of findings ‐ Ciklavit® vs placebo Frequency, severity or duration of painful crises · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | 1 study · 87 participants | Low |