Total mortality · Adults with oropharyngeal cancer
Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).
1 finding from 1 review
Locoregional recurrence · Adults with oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
MMP-9 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-9 showed no increase in irradiated vs non-irradiated carious dentin (one study; ungraded).
1 finding from 1 review
Disease-free survival · Adults with oropharyngeal cancer
Surgery showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with radiotherapy alone (low certainty).
1 finding from 1 review
Recurrence · Adults with oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
MMP-20 expression · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-20 shows no difference between irradiated and non-irradiated carious dentin; the evidence is very uncertain (very low certainty).
1 finding from 1 review
There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
1 study · 36 participants
Very low
Intervention not reported
Supportive care only*** (1 RCT, 81 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
1 finding from 1 review
Intervention not reported
TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…
The intervention showed no clear difference in TMZ (3 RCTs, 538 participants) (low certainty).
1 finding from 1 review
Intervention not reported
CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…
The intervention leads to lower CRT (2 RCTs; 635 participants) (high certainty).
1 finding from 1 review
Intervention not reported
BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…
The intervention probably leads to lower BEV_CRT (1 RCT; 73 participants) (moderate certainty).
1 finding from 1 review
Intervention not reported
RT 60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…
1 finding from 1 review
Intervention not reported
RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…
The intervention showed no clear difference in RT 40 (4 RCTs; 930 participants) (low certainty).
1 finding from 1 review
Intervention not reported
BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…
It is very uncertain whether the intervention changes BEV_RT (1 RCT; 75 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…
It is very uncertain whether the intervention changes TMZ (3 RCTs, 538 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…
The intervention may leads to lower CRT (2 RCTs; 635 participants) (low certainty).
1 finding from 1 review
Intervention not reported
BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…
The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.
1 finding from 1 review
Intervention not reported
RT60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention probably leads to lower RT60 (5 RCTs; 713 participants) (moderate certainty).
1 finding from 1 review
Intervention not reported
BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants); GRADE not reported.
1 finding from 1 review
Intervention not reported
RT40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention may leads to lower RT40 (4 RCTs; 930 participants) (low certainty).
1 finding from 1 review
Intervention not reported
TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention may leads to lower TMZ (3 RCTs, 538 participants) (low certainty).
1 finding from 1 review