Findings

What do systematic reviews say?

749 questions · 769 findings · 63 reviews · Headline outcomes only

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No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

Intramuscular vitamin K vs intravenous vitamin K

Sepsis diagnosed after randomisation: range 28 d to 60 d · preterm infants

Intramuscular vitamin K showed no clear difference in sepsis: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.86 [0.26, 2.86]
1 study · 54 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Mortality (all infants): 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in mortality (all infants): 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.32 [0.56, 3.14]
1 study · 67 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Mortality (all infants): 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in mortality (all infants): 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.82 [0.84, 9.46]
1 study · 64 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Bleeding complications: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in bleeding complications: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.12 [0.01, 2.11]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.36 [0.04, 3.24]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.36 [0.24, 7.57]
1 study · 61 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.96 [0.06, 14.6]
1 study · 53 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Necrotizing enterocolitis: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in necrotizing enterocolitis: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.08 [0.16, 7.1]
1 study · 54 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Bleeding complications: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in bleeding complications: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.81 [0.2, 3.27]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Sepsis: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in sepsis: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.86 [0.26, 2.86]
1 study · 54 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Mortality (all infants): 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in mortality (all infants): 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.13 [0.6, 7.51]
1 study · 65 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2 [0.19, 20.72]
1 study · 52 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.72 [0.13, 3.96]
1 study · 54 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 5: 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.52 [0.37, 6.23]
1 study · 60 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 5: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.07 [0.41, 10.43]
1 study · 57 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25: 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25: 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.08 [0.07, 16.36]
1 study · 52 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.04 [0.07, 15.74]
1 study · 51 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Necrotizing enterocolitis ‐ 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in necrotizing enterocolitis ‐ 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1 [0.15, 6.57]
1 study · 52 participants
Low

Intervention not reported

Cervical cancer ‐ not measured · adolescent girls and women aged 15 to 26 years who are hrHPV negative before vaccination

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Cervical cancer ‐ not measured · adolescent girls and women aged 15 to 45 years who were HPV16/18 negative before vaccination

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found