What do systematic reviews say?

Fluoxetine vs control at end of treatment,

Fluoxetine showed no clear difference in number of seizures compared with control at end of treatment, (moderate certainty).

• Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery 2021 · Cochrane Headline outcomes only
  RR 1.4 [1, 1.98]
  6 studies · 6080 participants
  Moderate

Fluoxetine vs control at end of treatment,

Fluoxetine leads to higher bone fractures compared with control at end of treatment, (high certainty).

• Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery 2021 · Cochrane Headline outcomes only
  RR 2.35 [1.62, 3.41]
  6 studies · 6080 participants
  High

Selective serotonin reuptake inhibitors vs placebo

SSRI probably leads to higher participant perception of change with treatment compared with placebo (moderate certainty).

• Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
  RR 1.92 [1.66, 2.23]
  6 studies · 3260 participants
  Moderate

Selective serotonin reuptake inhibitors vs placebo

SSRI probably leads to higher participant satisfaction with intercourse compared with placebo (moderate certainty).

• Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
  RR 1.63 [1.42, 1.87]
  3 studies · 4273 participants
  Moderate

Selective serotonin reuptake inhibitors vs placebo

SSRI may leads to higher study withdrawal due to adverse events compared with placebo (low certainty).

• Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
  RR 3.8 [2.61, 5.51]
  20 studies · 7367 participants
  Low

Selective serotonin reuptake inhibitors vs placebo

SSRI probably leads to higher perceived control over ejaculation compared with placebo (moderate certainty).

• Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
  RR 2.29 [1.72, 3.05]
  3 studies · 4273 participants
  Moderate

Selective serotonin reuptake inhibitors vs placebo

SSRI probably leads to higher participant distress about PE compared with placebo (moderate certainty).

• Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
  RR 1.54 [1.26, 1.88]
  1 study · 652 participants
  Moderate

Selective serotonin reuptake inhibitors vs placebo

SSRI probably leads to higher adverse events compared with placebo (moderate certainty).

• Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
  RR 1.71 [1.48, 1.99]
  17 studies · 4624 participants
  Moderate

Selective serotonin reuptake inhibitors vs placebo

• Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
  no estimate extracted
  20 studies · 5872 participants
  Low

Video modelling acclimatisation vs Acclimatisation in clinic (tell-show-do)

Video modelling acclimatisation showed no clear difference in pre- and post-operative anxiety measures (Venham's scale) compared with acclimatisation in clinic (tell-show-do); GRADE not reported.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  In advance of LA
  MD 0.13 [-0.37, 0.63]
  1 study · 46 participants
  GRADE not reported

Hypnosis vs Conventional treatment

Hypnosis led to lower physical/verbal resistance and self-reported pain during LA (other… compared with conventional treatment; GRADE not reported.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA · Oberoi 2016 (resistance)
  RR 0.47 [0.34, 0.65]
  1 study · 200 participants
  GRADE not reported

The wand (computer-controlled LA delivery system) vs Sleeper One (electronic LA delivery system)

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA (injection is the intervention)
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Video modelling acclimatisation for LA vs Oral hygiene video

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  In advance of LA
  Completion of dental treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Audiovisual distraction vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA
  Successful LA/painless treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Counter-stimulation or distraction vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA
  Completion of dental treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Counter-stimulation and distraction (combined) vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA
  Successful LA/painless treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Counter-stimulation and distraction (combined) vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA
  Successful LA/painless treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Hypnosis vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA
  Patient satisfaction: included studies did not report on this outcome
  Studies not reported
  No studies found