Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

606 questions · 682 findings · 77 reviews

No studies found 99 · 14.5%GRADE not reported 215 · 31.5%Very low 197 · 28.9%Low 102 · 15%Moderate 48 · 7%High 21 · 3.1%

Closed‐system transfer device plus safe handling vs safe handling alone

Cyclophosphamide alone · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes cyclophosphamide alone compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Cytarabine · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes cytarabine compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Gemcitabine · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes gemcitabine compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Irinotecan, docetaxel, paclitaxel, vinorelbine, ganciclovir, epirubicin, multiple drugsϯ · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes irinotecan, docetaxel, paclitaxel, vinorelbine, ganciclovir,… compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Cyclophosphamide · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes cyclophosphamide‡ compared with safe handling alone (very low certainty).

2 findings from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Epirubicin · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes epirubicin compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Cyclophosphamide or ifosfamide · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes cyclophosphamide or ifosfamide compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Ifosfamide · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes ifosfamide compared with safe handling alone (very low certainty).

1 finding from 1 review