Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,324 questions · 1,405 findings · 189 reviews

No studies found 402 · 28.6%GRADE not reported 294 · 20.9%Very low 323 · 23%Low 232 · 16.5%Moderate 117 · 8.3%High 37 · 2.6%

Arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement vs placebo

Development of any new foot ulcers · people with diabetes and foot ulcers

It is very uncertain whether arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement changes development of any new foot ulcers compared with placebo (very low certainty).

1 finding from 1 review

Physical activity vs usual care

Overall survival (time interval between enrolment in the study and death of the person from any cause) · adults with non‐advanced colorectal cancer treated surgically or with neoadjuvant or adjuvant therapy, or both

The review found no eligible studies for this question.

1 finding from 1 review

Counter-stimulation or distraction vs Conventional treatment

Intraoperative pain · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

It is very uncertain whether counter-stimulation or distraction changes self- or observational assessment of intraoperative… compared with conventional treatment (very low certainty).

1 finding from 1 review

The wand (computer-controlled LA delivery system) vs Sleeper One (electronic LA delivery system)

Self- or observational assessment of intraoperative distress/pain/acceptance of treatment during provision of LA: pain-related behaviour (any disruptive behaviour/sudden reaction/movement) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

It is very uncertain whether the wand (computer-controlled LA delivery system) changes self- or observational assessment of intraoperative… compared with sleeper One (electronic LA delivery system) (very low certainty).

1 finding from 1 review

INTEGRATED MODELS OF CARE vs usual care

Substance use: any change ‐ Alcohol use (not in remission) · people with both severe mental illness and substance misuse

Integrated models of care showed no clear difference in substance use: any change ‐ Alcohol use (not in remission) compared with standard care (low certainty).

1 finding from 1 review