Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged one to 12 years old

IMMEDIATE initiation of cART showed no clear difference in proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) compared with DEFERRED initiation of cART (low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Supplementary feeding vs no food supplementation or placebo

Weight‐for‐length/height z‐score at the end of the intervention Weight scale, measurement boards and child growth reference · Children aged less than five years with or without stunting/wasting in LMIC
1 finding from 1 review

Supplementary feeding vs no food supplementation or placebo

Weight‐for‐length/height z‐score at the end of the intervention Weight scale, measurement boards and child growth reference · Children aged less than five years in LMIC
2 findings from 1 review

Steam inhalation (mist) vs salbutamol

change in respiratory distress score at 30 minutes Scale from: 0 to 13. · patients with acute bronchiolitis in children up to three years of age
2 findings from 1 review

Steam (mist) vs nebulised 0.9% saline

change in respiratory distress score at 30 minutes Scale from: 0 to 13. · patients with acute bronchiolitis in children up to three years of age
2 findings from 1 review