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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,956 questions in 143 reviews · Musculoskeletal
current versionsNo studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Allopurinol vs placebo Tophus regression · people with chronic gout Allopurinol for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Allopurinol vs placebo Withdrawal due to adverse events · people with chronic gout Allopurinol for chronic gout (2014) · Cochrane | RR 1.36 [0.61, 3.08] | 2 studies · 453 participants | Moderate |
Allopurinol vs placebo Serious adverse events · people with chronic gout Allopurinol for chronic gout (2014) · Cochrane | RR 1.93 [0.48, 7.8] | 2 studies · 453 participants | Moderate |
Allopurinol 100‐300 mg daily vs febuxostat 80 mg daily Acute gout attacks · people with chronic gout Allopurinol for chronic gout (2014) · Cochrane | RR 0.89 [0.71, 1.1] | 3 studies · 1136 participants | Low |
Allopurinol 100‐300 mg daily vs febuxostat 80 mg daily Proportion achieving target serum urate · people with chronic gout Allopurinol for chronic gout (2014) · Cochrane | RR 0.56 [0.48, 0.65] | 4 studies · 2618 participants | Low |
Intervention NR Pain Self report · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | no estimate extracted | 9 studies · 549 participants | High |
Intervention NR Physical function · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | no estimate extracted | 9 studies · 521 participants | High |
Intervention NR Quality of life · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | no estimate extracted | 3 studies · 183 participants | Low |
Intervention NR Withdrawals or dropouts · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | OR 1.77 [0.86, 3.65] | 7 studies · 715 participants | Moderate |
Intervention NR Adverse events not reported · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Pain · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | no estimate extracted | 6 studies · 391 participants | High |
Intervention NR Physical Function · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | no estimate extracted | 6 studies · 365 participants | High |
Intervention NR Adverse events not reported · people with osteoarthritis of the hip Exercise for osteoarthritis of the hip (2014) · Cochrane | no estimate extracted | NR | No studies |
SMP vs Attention control Self‐management of OA Arthritis self‐efficacy scale (ASES). Scale from 1 to 10, higher better · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 344 participants | Low |
SMP vs usual care Pain Multiple tools6 · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 14 studies · 2083 participants | Moderate |
SMP vs usual care Global OA scores Multiple tools8 · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 1957 participants | Moderate |
SMP vs usual care Function—Self‐reported Scale from 0 to 68. Lower score is better · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 13 studies · 2254 participants | Moderate |
SMP vs usual care Quality of life Multiple tools11 · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 1383 participants | Moderate |
SMP vs usual care Withdrawals Losses to · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | RR 0.99 [0.74, 1.33] | 16 studies · 3738 participants | Low |
SMP vs information only Self‐management of OA Multiple tools1. Scale from 5 to 35 points (higher better) · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 760 participants | Moderate |
SMP vs information only Positive and active engagement in life heiQ subscale for positive and active engagement in life. Scale from 1 to 6 (higher better) · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 93 participants | Low |
SMP vs information only Pain WOMAC subscale for pain . Scale from 0 to 20 (lower better) · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 751 participants | Moderate |
SMP vs information only Global OA scores Multiple tools6. Scale from 0 to 96 (lower score better) · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 751 participants | Moderate |
SMP vs information only Self‐reported function Multiple tools7. Scale from 0 to 68 (lower better) · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 854 participants | Moderate |
SMP vs Attention control Positive and active engagement in life —not measured · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | NR | No studies |
SMP vs information only Quality of life Multiple tools8. Scale from 0 to 100 (higher better) · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 648 participants | Moderate |
SMP vs information only Withdrawals Losses to · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | RR 1.6 [0.75, 3.4] | 1251 participants | Low |
SMP vs non‐SMP intervention Self‐management of OA Arthritis self‐efficacy scale. Scale from 30 to 300. · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 175 participants | Moderate |
SMP vs non‐SMP intervention Positive and active engagement in life Not measured · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
SMP vs non‐SMP intervention Pain Multiple tools3. Scale from 0 to 20. Lower score is better. · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 321 participants | Moderate |
SMP vs non‐SMP intervention Global OA scores WOMAC. Scale from 0 to 240. Lower score is better. · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 98 participants | Moderate |
SMP vs non‐SMP intervention Function—Self‐reported Multiple tools3. Scale from 0 to 68. Lower score is better. · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 216 participants | Moderate |
SMP vs non‐SMP intervention Quality of life Multiple tools6. Scale from 0 to 1. Higher score is better. · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 226 participants | Moderate |
SMP vs non‐SMP intervention Withdrawals Losses to · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | RR 0.86 [0.69, 1.09] | 919 participants | Moderate |
SMP vs Attention control Pain Multiple tools4. Scale from: 0 to 10, 0 = no pain · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 575 participants | Low |
SMP vs Attention control Global OA scores AIMS2 (average of physical, affect, and pain subscales). Scale from 0 to 10, lower better · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 251 participants | Low |
SMP vs Attention control Self‐reported function Multiple tools.7 Lower score better · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 574 participants | Low |
SMP vs Attention control Quality of life Quality of well‐being scale. Scale from 0 to 1, higher better · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 165 participants | Low |
SMP vs Attention control Withdrawals · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | RR 1.11 [0.78, 1.57] | 937 participants | Moderate |
SMP vs usual care Self‐management of OA Multiple tools1. Scale from 1 to 10, higher better · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 11 studies · 1706 participants | Moderate |
SMP vs usual care Positive and active engagement in life Multiple tools4 · patients with osteoarthritis Self‐management education programmes for osteoarthritis (2014) · Cochrane | no estimate extracted | 357 participants | Moderate |
Canakinumab vs triamcinolone acetonide Pain: at 72 hours (canakinumab 150 mg) · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | 2 studies · 443 participants | Moderate |
Rilonacept vs indomethacin Functional disability ‐ not measured · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Rilonacept vs indomethacin Health‐related quality of life ‐ not measured · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Rilonacept vs indomethacin Participant global assessment of treatment success ‐ not measured · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Rilonacept vs indomethacin Adverse events ‐ study withdrawals due to adverse events · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | RR 0.51 [0.05, 5.47] | 1 study · 151 participants | Low |
Rilonacept vs indomethacin Adverse events ‐ participants with at least 1 adverse event · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | RR 1.19 [0.75, 1.88] | 1 study · 151 participants | Low |
Canakinumab vs triamcinolone acetonide Inflammation: participants with no swelling at 72 hours (canakinumab 150 mg) Assessed by the investigator as no swelling, mild/palpable, moderate/visible, severe/bulging beyond the joint margins · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | RR 1.39 [1.11, 1.74] | 3 studies · 523 participants | Moderate |
Canakinumab vs triamcinolone acetonide Functional disability ‐ not measured · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Canakinumab vs triamcinolone acetonide Health‐related quality of life ‐ not measured · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | NR | No studies |