Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

647 questions · 674 findings · 100 reviews

No studies found 129 · 19.1%GRADE not reported 95 · 14.1%Very low 220 · 32.6%Low 142 · 21.1%Moderate 64 · 9.5%High 24 · 3.6%

Flossing plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes plaque compared with flossing plus toothbrushing (very low certainty).

1 finding from 1 review · compare the 2 reviews

Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes gingivitis (proportion of bleeding sites) compared with interdental brushing plus toothbrushing (very low certainty).

2 findings from 1 review

Oral irrigation plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

Wooden cleaning stick plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

2 findings from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Recovery during intervention defined as achieving WHZ ≥ −2 and absence of oedema in 1 study; reaching a WHZ score > −2 and without oedema in 1 study; WHZ > −2 in 1 study; having a WHZ score ≥ 0 in 1 study; reaching 100% weight for height in 1 stud... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… probably leads to higher recovery during intervention defined as achieving WHZ ≥ −2 and… compared with an alternative dietary approach (moderate certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Relapse during intervention defined as admission to inpatient therapeutic care, remain wasted, and dropouts during intervention period · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) leads to lower relapse during intervention defined as admission to inpatient… compared with RUTF using an alternative formulation (high certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Mortality during intervention · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) showed no clear difference in mortality during intervention compared with RUTF using an alternative formulation (moderate certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes relapse during intervention defined as admission to inpatient… compared with an alternative dietary approach (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Mortality during intervention · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes mortality during intervention compared with an alternative dietary approach (very low certainty).

1 finding from 1 review