Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

534 questions · 539 findings · 63 reviews · Pregnancy and Childbirth

No studies found 101 · 18.7%GRADE not reported 63 · 11.7%Very low 93 · 17.3%Low 167 · 31%Moderate 89 · 16.5%High 26 · 4.8%

Computerised antenatal CTG vs traditional antenatal CTG (women at increased risk of complications)

Perinatal mortality · Pregnant women with/without complications

Computerised antenatal CTG probably leads to lower perinatal mortality compared with traditional antenatal CTG (women at increased risk of complications) (moderate certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Neural tube defects (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate leads to lower neural tube defects (All) compared with no intervention, placebo or other micronutrients without folate… (high certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Miscarriage · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Cleft lip (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in cleft lip (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Cleft palate (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in cleft palate (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Congenital cardiovascular anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in congenital cardiovascular anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Other congenital anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in other congenital anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review