Findings

What do systematic reviews say?

1,126 questions · 1,225 findings · 111 reviews

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No studies found 235 · 19.2%GRADE not reported 260 · 21.2%Very low 207 · 16.9%Low 271 · 22.1%Moderate 177 · 14.4%High 75 · 6.1%

Vitamin D 100,000 IU/month vs 12,000 IU/month

Adverse events · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Low

Vitamin D 100,000 IU/month vs 12,000 IU/month

Pain: presence of pain (slight or moderate) at 1 year · people with sickle cell disease

Vitamin D 100,000 IU/month showed no clear difference in presence of pain compared with 12,000 IU/month (moderate certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1 [0.62, 1.62]
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

Acute chest syndrome ( · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

Respiratory infections · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

HRQoL (using a validated scale) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D 100,000 IU/month vs 12,000 IU/month

Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

Overall improvement in CTS: SSS: short term (< 3 months) Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

Overall improvement in CTS: SSS: long term ‐ not measured · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

Overall improvement in CTS: FSS: short term (< 3 months) Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

Overall improvement in CTS: FSS: long term ‐ not reported · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

Adverse events · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral vitamin B vs no treatment

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

1 finding from 1 review

Interventions for leg cramps in pregnancy 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Vitamin A plus iron plus folate vs iron plus folate

Any adverse effects · pregnant women

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin supplementation for preventing miscarriage 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Low birthweight · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in low birthweight (less than 2500 g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
RR 0.82 [0.55, 1.22]
8 studies · 1898 participants
Low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Participants with at least some Side Effects · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes side effects (any reported throughout intervention period) compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
RR 0.56 [0.37, 0.84]
11 studies · 1777 participants
Very low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Severe anaemia at any time during second and third trimester (Hb less than 70 g/L) · Women receiving supplements in pregnancy

1 finding from 1 review

Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1240 participants
Very low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal clinical malaria or other infection in pregnancy · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… led to lower maternal clinical malaria or other infection in pregnancy compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.

1 finding from 1 review

Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
RR 0 [0, 0]
0 studies · 0 participants
GRADE not reported

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Birthweight (g) · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in birthweight (g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
MD 5.13
9 studies · 1939 participants
Low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Gestational age (preterm birth < 37 weeks) · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in premature birth (less than 37 weeks of gestation) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
RR 1.03 [0.76, 1.39]
5 studies · 1177 participants
Low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Neonatal mortality · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes neonatal death (within 28 days after delivery) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (very low certainty).

1 finding from 1 review

Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
RR 0.49 [0.04, 5.42]
1 study · 795 participants
Very low