Disease-free survival · Patients treated with curative intent for colorectal cancer with neoadjuvant and/or adjuvant chemotherapy
Oral showed no clear difference in disease‐free survival compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
Grade ≥ 3 neutropenia/granulocytopenia · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral may leads to lower grade ≥ 3 neutropenia/granulocytopenia compared with intravenous fluoropyrimidines (low certainty).
1 finding from 1 review
Overall survival · Patients treated with curative intent for colorectal cancer with neoadjuvant and/or adjuvant chemotherapy
Oral showed no clear difference in overall survival compared with intravenous fluoropyrimidines (high certainty).
1 finding from 1 review
Grade ≥ 3 diarrhoea · Patients treated with curative intent for colorectal cancer with neoadjuvant and/or adjuvant chemotherapy
It is very uncertain whether oral changes grade ≥ 3 diarrhoea compared with intravenous fluoropyrimidines (very low certainty).
1 finding from 1 review
Hand‐foot syndrome (grade ≥ 3) · Patients treated with curative intent for colorectal cancer with neoadjuvant and/or adjuvant chemotherapy
Oral may leads to higher grade ≥ 3 hand foot syndrome compared with intravenous fluoropyrimidines (low certainty).
1 finding from 1 review
Grade ≥ 3 neutropenia/granulocytopenia · Patients treated with curative intent for colorectal cancer with neoadjuvant and/or adjuvant chemotherapy
Oral probably leads to lower grade ≥ 3 neutropenia/granulocytopenia compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
Progression‐free survival · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral probably leads to higher progression‐free survival compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
Overall survival · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral showed no clear difference in overall survival compared with intravenous fluoropyrimidines (high certainty).
1 finding from 1 review
Grade ≥ 3 diarrhoea · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral may leads to higher grade ≥ 3 diarrhoea compared with intravenous fluoropyrimidines (low certainty).
1 finding from 1 review
Hand‐foot syndrome (grade ≥ 3) · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral probably leads to higher grade ≥ 3 hand foot syndrome compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
Pain in the PACU (VAS) · adults undergoing transabdominal robotic assisted laparoscopic surgery
1 finding from 1 review
Pain at 1 to 6 hours (VAS) · adults undergoing transabdominal robotic assisted laparoscopic surgery
1 finding from 1 review
Pain at 6 to 24 hours (VAS) · adults undergoing transabdominal robotic assisted laparoscopic surgery
1 finding from 1 review
Nausea · adults undergoing transabdominal robotic assisted laparoscopic surgery
Inhalational anaesthesia may leads to lower presence of nausea compared with intravenous anaesthesia (low certainty).
3 findings from 1 review
RR 0.39 [0.19, 0.8]
1 study · 62 participants
Low
no estimate extracted
1 study · 62 participants
Low
no estimate extracted
1 study · 62 participants
Low
Nausea and vomiting · adults undergoing transabdominal robotic assisted laparoscopic surgery
It is very uncertain whether inhalational anaesthesia changes nausea‐vomiting rate at 1 hour compared with intravenous anaesthesia (very low certainty).
2 findings from 1 review
Adverse effects: IOP spikes · adults undergoing transabdominal robotic assisted laparoscopic surgery
1 finding from 1 review
Pain during cannulation · pain treatment during intravenous cannulation
1 finding from 1 review
Adverse events ‐ pain with topical application · pain treatment during intravenous cannulation
1 finding from 1 review
First‐attempt success rate · pain treatment during intravenous cannulation
Vapocoolant showed no clear difference in first attempt success compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Adverse events · pain treatment during intravenous cannulation
1 finding from 1 review