Findings

What do systematic reviews say?

2,327 questions · 2,494 findings · 87 reviews · All outcomes

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No studies found 450 · 18%GRADE not reported 1,487 · 59.6%Very low 385 · 15.4%Low 121 · 4.9%Moderate 50 · 2%High 1 · 0%

Occlusal loading vs Non-occlusal loading

Prosthesis failure · Patients who are having osseointegrated root-form dental implants

Occlusal loading showed no clear difference in prosthesis failure compared with non-occlusal loading; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 1.00 [0.31, 3.22]
2 studies
GRADE not reported

Immediate loading vs Conventional loading

Prosthesis failure · Patients who are having osseointegrated root-form dental implants

It is very uncertain whether immediate loading changes prosthesis failure compared with conventional loading (very low certainty).

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 1.90 [0.67, 5.34]
8 studies · 381 participants
Very low

Antibiotics (systemic) vs No antibiotics, placebo, or a different type of antibiotic

Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes
Minimum 12 months follow-up
Types of antibiotics: the effect of using no antibiotics, a placebo or different types of antibiotics. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in this review.
0 studies
No studies found

Immediate loading vs Conventional loading

Implant failure · Patients who are having osseointegrated root-form dental implants

Immediate loading showed no clear difference in implant failure compared with conventional loading; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 1.50 [0.60, 3.77]
10 studies
GRADE not reported

Dental repositioning vs Spontaneous re-eruption, orthodontic repositioning, or surgical repositioning

Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes
Minimum 12 months follow-up
Types of dental repositioning: to compare spontaneous re-eruption, orthodontic repositioning or surgical repositioning. Main results: No randomised or quasi-randomised controlled trials were found; no study was…
0 studies
No studies found

Immediate loading vs Early loading

Implant failure · Patients who are having osseointegrated root-form dental implants

Immediate loading showed no clear difference in implant failure compared with early loading; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 0.65 [0.26, 1.64]
5 studies
GRADE not reported

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

Aesthetics · Participants who previously underwent orthodontic treatment, with subsequent crowding (relapse) of the lower front teeth (lower incisors…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
0 studies
No studies found

Root canal medicaments vs No medicaments, placebo, or a different type of medicament

Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes
Minimum 12 months follow-up
Types of root canal medicaments: this was compared with no medicaments, placebo and different types of medicaments. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in…
0 studies
No studies found

Early loading vs Conventional loading

Prosthesis failure · Patients who are having osseointegrated root-form dental implants

It is very uncertain whether early loading changes prosthesis failure compared with conventional loading (very low certainty).

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 5.00 [0.63, 39.67]
1 study · 48 participants
Very low

Fixation (splinting) vs No splint, or a different type or duration of splint

Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes
Minimum 12 months follow-up
Types and duration of fixation: the effect of using no splint or different types of splints and their duration. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in…
0 studies
No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

Assessment of the alignment of the lower front teeth using any method or index · Participants who previously underwent orthodontic treatment, with subsequent crowding (relapse) of the lower front teeth (lower incisors…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
0 studies
No studies found

Levamisole (150 mg per day) vs placebo

Relief of pain · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Levamisole (150 mg per day) showed no clear difference in decrease in pain compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
RR 4.29 [0.67, 27.24]
1 study
GRADE not reported

Multivitamin vs placebo

Average mouth pain during RAS episodes · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in average mouth pain during RAS episodes compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
MD -0.05 [-0.71, 0.61]
1 study
GRADE not reported

Levamisole (150 mg per day) vs placebo

Decrease in frequency of attacks · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Levamisole (150 mg per day) showed no clear difference in decrease in frequency of attacks compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
RR 4.29 [0.72, 25.39]
1 study
GRADE not reported

Levamisole (150 mg per day) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
Patients receiving levamisole reported more adverse effects than those receiving placebo (mild stomach upset/nausea, diarrhoea, sleeplessness, dysgeusia/dysosmia), however no adverse effects were reported as requiring…
8 studies
GRADE not reported

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

Time to resolution of first ulcer (days) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Prednisone (oral, commencing 25 mg with phased dose reduction over 2… led to lower time to resolution of first ulcer (days) compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
2 months
MD -6.35 [-6.74, -5.96]
1 study · 40 participants
GRADE not reported

Bee propolis (one 500 mg capsule per day) vs placebo

Quality of life · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months (minimum)
Patients in the propolis group self-reported a significant improvement in their quality of life (P=0.03), based on volunteered statements of self-reported improvement.
1 study · 19 participants
GRADE not reported

Levamisole (150 mg per day) vs placebo

Effectiveness · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
Eight trials (seven high, one unclear risk of bias) compared levamisole 150 mg/day with placebo (De Cree 1978; Drinnan 1978; Meyer 1977; Miller 1978; Olson 1978; Van de Heyning 1978; Weckx 2009; Zissis 1983).…
8 studies
GRADE not reported

Sulodexide (heparin plus dermatan sulphate chains) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
Sulodexide was not associated with significant adverse events.
1 study · 20 participants
GRADE not reported

Sulodexide (heparin plus dermatan sulphate chains) vs placebo

Days to resolution of pain / epithelialization; number of aphthae per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
The trial by Femiano 2003 (high risk of bias) also compared sulodexide with placebo. Data were incompletely presented (ranges/totals only) precluding further analysis.
1 study · 20 participants
GRADE not reported