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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Population

Intervention or exposure

Comparison

Outcome

Any field or review title

Field or topic

Source

Review versions

1,518 questions in 135 reviews · Infectious Diseases

current versions

No studies 135 · 8.9%Ungraded 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Intervention NR Mortality All‐cause death · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 1.47 [0.42, 5.21]	1 study · 2239 participants	Very low
Intervention NR Severe anaemia During the third trimester · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.96 [0.41, 2.25]	2 studies · 2682 participants	Low
Intervention NR Anaemia · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	1 study · 244 participants	Very low
Intervention NR Uncomplicated clinical malaria · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Severe anaemia During the third trimester · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.6 [0.47, 0.75]	3 studies · 2503 participants	High
Intervention NR Antenatal parasitaemia · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.38 [0.28, 0.5]	4 studies · 3022 participants	High
Intervention NR Severe adverse events11 · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Spontaneous abortion · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Stillbirth · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Perinatal deaths · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Neonatal mortality · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 1.46 [0.9, 2.38]	1 study · 2017 participants	Very low
Intervention NR Preterm birth · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Low birthweight · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.86 [0.63, 1.17]	3 studies · 2743 participants	Low
Intervention NR Mean birthweight · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Placental parasitaemia · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Anaemia · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.83 [0.74, 0.93]	5 studies · 3662 participants	High
Intervention NR Cord blood haemoglobin · Pregnant women (parity 2+) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Mortality All‐cause death · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.84 [0.25, 2.74]	4 studies · 6026 participants	Low
Intervention NR Severe anaemia During the third trimester · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.19 [0.05, 0.75]	2 studies · 1327 participants	Low
Intervention NR Anaemia · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 1.03 [0.87, 1.23]	3 studies · 3027 participants	Moderate
Intervention NR Uncomplicated clinical malaria · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.37 [0.11, 1.23]	4 studies · 3455 participants	Low
Intervention NR Antenatal parasitaemia · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.7 [0.44, 1.13]	4 studies · 3455 participants	Low
Intervention NR Severe adverse effects12 · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Spontaneous abortion · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.89 [0.58, 1.36]	3 studies · 5767 participants	Low
Intervention NR Stillbirth · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 1.02 [0.76, 1.36]	5 studies · 7130 participants	Moderate
Intervention NR Perinatal mortality · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 1.24 [0.94, 1.63]	4 studies · 5216 participants	Moderate
Intervention NR Uncomplicated clinical malaria · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.37 [0.18, 0.74]	2 studies · 307 participants	Low
Intervention NR Neonatal mortality · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.91 [0.71, 1.16]	5 studies · 6313 participants	Moderate
Intervention NR Preterm birth · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.95 [0.65, 1.38]	2 studies · 1174 participants	Low
Intervention NR Low birthweight · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 1.06 [0.89, 1.27]	4 studies · 3644 participants	Low
Intervention NR Mean birthweight · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	5 studies · 6007 participants	Moderate
Intervention NR Placental parasitaemia · Pregnant women (all parities) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.44 [0.15, 1.29]	4 studies · 3200 participants	Low
Intervention NR Mortality All‐cause death · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 1.15 [0.44, 3.06]	2 studies · 2097 participants	Very low
Intervention NR Severe anaemia During the third trimester · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.6 [0.47, 0.75]	3 studies · 2503 participants	High
Intervention NR Anaemia · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.88 [0.81, 0.96]	4 studies · 3291 participants	Moderate
Intervention NR Uncomplicated clinical malaria · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.24 [0.05, 1.12]	1 study · 174 participants	Very low
Intervention NR Antenatal parasitaemia · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.38 [0.24, 0.59]	4 studies · 2832 participants	High
Intervention NR Antenatal parasitaemia · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.39 [0.26, 0.58]	8 studies · 3663 participants	High
Intervention NR Severe adverse effects13 · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Spontaneous abortion · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.61 [0.38, 0.99]	3 studies · 2567 participants	Low
Intervention NR Stillbirth · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.97 [0.64, 1.47]	3 studies · 2703 participants	Low
Intervention NR Perinatal mortality · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.78 [0.52, 1.17]	1 study · 1237 participants	Low
Intervention NR Neonatal mortality · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.62 [0.37, 1.05]	2 studies · 2156 participants	Low
Intervention NR Preterm birth · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.85 [0.66, 1.1]	2 studies · 1493 participants	Low
Intervention NR Low birthweight · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.81 [0.67, 0.99]	4 studies · 3043 participants	Moderate
Intervention NR Mean birthweight · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	3 studies · 2127 participants	Moderate
Intervention NR Placental parasitaemia · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.45 [0.33, 0.61]	3 studies · 1633 participants	Moderate
Intervention NR Cord blood haemoglobin · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Intervention NR Severe adverse effects12 · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Spontaneous abortion · Pregnant women (parity 0‐1) Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no… (2014) · Cochrane	RR 0.65 [0.41, 1.02]	5 studies · 2876 participants	Low