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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
ACE inhibitors vs placebo Any reported adverse effect or toxicity · adults and children with proteinuria or microalbuminuria due to sickle cell disease Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle… (2021) · Cochrane | no estimate extracted | 1 study · 22 participants | Very low |
Autogenic drainage vs conventional physiotherapy FEV1 % predicted (change from baseline) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 2 studies · 54 participants | Very low |
Autogenic drainage vs spontaneous cough Participant preference · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough Exercise tolerance · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 14 participants | Very low |
Autogenic drainage vs spontaneous cough Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough Need for extra treatment · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs active cycle of breathing technique FEV1 (L) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 2 studies · 44 participants | Low |
Autogenic drainage vs active cycle of breathing technique QoL (SF‐36 and CRQ) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs active cycle of breathing technique Participant preference · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 2 studies · 44 participants | Very low |
Autogenic drainage vs active cycle of breathing technique Exercise tolerance (modified shuttle test) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs active cycle of breathing technique Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 18 participants | Very low |
Autogenic drainage vs conventional physiotherapy QoL (Likert scale 0 ‐ 10) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 2 studies · 54 participants | Very low |
Autogenic drainage vs active cycle of breathing technique Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs active cycle of breathing technique Need for extra treatment · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs positive expiratory pressure FEV1 (L) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 3 studies · 62 participants | Low |
Autogenic drainage vs positive expiratory pressure QoL (SF‐36 and CRQ) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs positive expiratory pressure Participant preference · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs positive expiratory pressure Exercise tolerance: modified shuttle test · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs positive expiratory pressure Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs positive expiratory pressure Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs positive expiratory pressure Need for extra treatment · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs Cornet® FEV1 (L) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 27 participants | Moderate |
Autogenic drainage vs conventional physiotherapy Participant preference · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 36 participants | Very low |
Autogenic drainage vs Cornet® QoL (SF‐36 and CRQ) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs Cornet® Participant preference · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs Cornet® Exercise tolerance: modified shuttle test · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Cornet® Adverse events · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Cornet® Number of admissions to hospital · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Cornet® Need for extra treatment · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs Flutter® FEV1 (L) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 2 studies · 39 participants | Low |
Autogenic drainage vs Flutter® QoL (SF‐36 and CRQ) · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs Flutter® Participant preference · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs Flutter® Exercise tolerance: modified shuttle test · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs conventional physiotherapy Exercise tolerance · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Flutter® Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Flutter® Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Flutter® Need for extra treatment · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 30 participants | Low |
Autogenic drainage vs high frequency chest wall oscillation FEV1 · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation QoL · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Participant preference · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Exercise tolerance (modified shuttle test) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Adverse events · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Number of admissions to hospital · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Need for extra treatment · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs conventional physiotherapy Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) FEV1% predicted (change from baseline) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | 1 study · 4 participants | Very low |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) QoL · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) Participant preference · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) Exercise tolerance (modified shuttle test) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |