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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

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No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

Anaerobic coverage only vs gram‐negative and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes intra‐abdominal infection compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐negative and anaerobic coverage vs gram‐positive, gram‐negative, and anaerobic coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐negative and anaerobic coverage changes abdominal surgical site infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐negative and anaerobic coverage vs gram‐positive, gram‐negative, and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐negative and anaerobic coverage changes intra‐abdominal infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐positive and gram‐negative coverage vs gram‐negative and anaerobic coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐positive and gram‐negative coverage changes abdominal surgical site infection compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

More than 24 hours of antibiotics vs 24 hours of antibiotics

All‐cause mortality · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether more than 24 hours of antibiotics changes mortality compared with 24 hours of antibiotics (very low certainty).

1 finding from 1 review

Gram‐positive and gram‐negative coverage vs gram‐negative and anaerobic coverage

All‐cause mortality · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐positive and gram‐negative coverage changes mortality compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐positive and gram‐negative coverage vs gram‐negative and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐positive and gram‐negative coverage changes intra‐abdominal infection compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

More than 24 hours of antibiotics vs 24 hours of antibiotics

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether more than 24 hours of antibiotics changes intra‐abdominal infection compared with 24 hours of antibiotics (very low certainty).

1 finding from 1 review

Single‐dose antibiotic vs 24 hours of antibiotics

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether single dose of antibiotics changes abdominal surgical site infection compared with 24 hours of antibiotics (very low certainty).

1 finding from 1 review

Single‐dose antibiotic vs 24 hours of antibiotics

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether single dose of antibiotics changes intra‐abdominal infection compared with 24 hours of antibiotics (very low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐positive, gram‐negative, and anaerobic coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes abdominal surgical site infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐positive, gram‐negative, and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes intra‐abdominal infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Major bleeding · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes major bleeding within 24 hours № of participants: 60 (1 RCT) compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Number of individuals requiring a transfusion within 7 days № of participants: 60 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

Thromboelastography threshold may leads to lower number of individuals requiring a transfusion within 7 days № of… compared with standard of care (laboratory parameters) (low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes serious adverse events measured by plasma transfusion‐related… compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review