Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

974 questions · 987 findings · 137 reviews

No studies found 182 · 18.4%GRADE not reported 90 · 9.1%Very low 165 · 16.7%Low 312 · 31.6%Moderate 163 · 16.5%High 75 · 7.6%

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings for selective ß2‐adrenergic agonist vs no tocolytic agent, whilst awaiting emergency delivery

Perinatal death or severe morbidity · women with fetal distress for whom the decision had been made to delivery by emergency caesarean section

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Caesarean section · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate probably leads to higher caesarean delivery compared with emergency delivery (moderate certainty).

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Apgar score less than 7 at 5 minutes · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate showed no clear difference in 5‐minute Apgar score < 7 compared with emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Umbilical artery pH < 7.1 · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate showed no clear difference in umbilical artery pH < 7.1 compared with emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Perinatal death or severe morbidity · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Apgar score less than 7 at 5 minutes · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

Summary of findings for IV hexoprenaline showed no clear difference in 5‐minute Apgar score < 7 compared with no tocolytic agent, whilst awaiting emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Low umbilical artery pH (< 7.2 or as defined by trial authors) · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

Summary of findings for IV hexoprenaline showed no clear difference in umbilical artery pH < 7.2 compared with no tocolytic agent, whilst awaiting emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Abnormal FHR as defined by trial authors (FHR tracing not improved) · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

Summary of findings for IV hexoprenaline probably leads to lower FHR tracing not improved compared with no tocolytic agent, whilst awaiting emergency delivery (moderate certainty).

1 finding from 1 review