What do systematic reviews say?

Systemic oral acyclovir vs placebo or no treatment

• Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
  Amir 1997b: two children in each group (2 vs 2) had mild gastrointestinal symptoms that resolved spontaneously after 24 to 48 hours without a change in study treatment. Ducoulombier 1988: no significant adverse effects…
  2 studies
  GRADE not reported

Occlusal intervention as an adjunct to periodontal therapy vs Sham (placebo) occlusal intervention as an adjunct to periodontal therapy

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Systemic oral acyclovir vs placebo or no treatment

The review found no eligible studies for this question.

• Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
  No data were available in either included study (Amir 1997b; Ducoulombier 1988).
  Studies not reported
  No studies found

Systemic oral acyclovir vs placebo or no treatment

• Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
  Amir 1997b: no data available. Ducoulombier 1988: time to resolution of pain, acyclovir (1 day=1, 2 days=1, 3 days=3, 4 days=3, 5 days=1, persistent=0) vs placebo (1 day=0, 2 days=0, 3 days=1, 4 days=2, 5 days=4,…
  1 study · 18 participants
  GRADE not reported

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.01 [-0.20, 0.22]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to non-surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.38 [0.04, 0.72]
  1 study · 50 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997 observed and rated participants on flossing skill; Analysis of Covariance found a significant difference favouring the intervention group.
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  The impact of psychological interventions on clinical markers was assessed in three studies (Little 1997; Stewart 1991; Weinstein 1996). All three found that psychological interventions resulted in improved plaque…
  3 studies
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Stewart 1996: the psychological intervention group demonstrated significantly higher change in self efficacy scores for flossing at post-intervention compared to the other two groups (control and educational). Flossing…
  1 study · 117 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs attention control

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Weinstein 1996 reported that the psychological intervention led to improvements in plaque score greater than that noted in the attention control group; however the sample size in each arm was very small (n=5) and the…
  2 studies
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997: no change in pocket depth; there were no differences between the intervention and control groups in overall change in pocket depth. (Some analyses suggested greater change in the intervention group when…
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997 reported decreased gingival bleeding in the active intervention group: gingival bleeding present in 9% of the intervention group at baseline and 4% at 4-month follow up, versus 10% of the control group on…
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997: no change in attachment loss; no differences between the intervention and control groups in overall change in attachment (loss of attachment) markers.
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs attention control

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  5 weeks (2 weeks post-intervention)
  Stewart 1991: there were no differences between the attention control group and the cognitive behavioural (psychological) intervention group for self reported flossing; it cannot be concluded that the cognitive…
  1 study · 50 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997 observed and rated participants on brushing skill; Analysis of Covariance found a significant difference favouring the intervention group (one of four measures on which significant differences were found…
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Stewart 1996: for dental knowledge the control group showed no change pre- and post-intervention, whereas the psychological intervention group improved dental knowledge significantly (both intervention groups improved…
  1 study · 117 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs Educational intervention (oral hygiene education/instruction)

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  5 weeks (2 weeks post-intervention)
  Stewart 1991: for self reported brushing only the comparison of the control group with the cognitive behavioural intervention was significant; the cognitive behavioural (psychological) intervention showed no…
  1 study · 50 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Stewart 1996: the psychological intervention had no discernible effect on self efficacy beliefs concerning tooth brushing; the data on perceived self efficacy for tooth brushing were not analysed due to ceiling effects…
  1 study · 117 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Self assessed flossing was assessed in two studies (Little 1997; Stewart 1991); both reported improvements for the intervention groups. Little 1997: Analysis of Covariance found significant differences favouring the…
  2 studies
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs attention control

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  5 weeks (2 weeks post-intervention)
  Stewart 1991: for self reported brushing only the comparison of the control group with the cognitive behavioural intervention was significant; the cognitive behavioural (psychological) intervention conveyed no…
  1 study · 50 participants
  GRADE not reported