Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 674 findings · 79 reviews · Gut

No studies found 116 · 17.2%GRADE not reported 14 · 2.1%Very low 133 · 19.7%Low 225 · 33.4%Moderate 145 · 21.5%High 41 · 6.1%

Mesalamine vs placebo

Histological response · Patients with collagenous colitis

Mesalamine showed no clear difference in histological response compared with placebo (low certainty).

1 finding from 1 review

Mesalamine vs placebo

Withdrawals due to adverse events · Patients with collagenous colitis

Mesalamine showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Mesalamine vs placebo

Serious adverse events · Patients with collagenous colitis

Mesalamine showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Probiotics vs placebo

Clinical response · Patients with collagenous colitis

It is very uncertain whether probiotics changes clinical response compared with placebo (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Adverse events · Patients with collagenous colitis

It is very uncertain whether probiotics changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Budesonide vs placebo

Clinical response sensitivity analysis excluding Miehlke 2014 · Patients with collagenous colitis

Budesonide may leads to higher clinical response sensitivity analysis excluding Miehlke 2014 compared with placebo (low certainty).

1 finding from 1 review

Budesonide vs placebo

Histological response sensitivity analysis excluding Miehlke 2014 · Patients with collagenous colitis

Budesonide may leads to higher histological response sensitivity analysis excluding Miehlke 2014 compared with placebo (low certainty).

1 finding from 1 review

Budesonide vs placebo

Maintenance of clinical response · Patients with collagenous colitis

Budesonide may leads to higher maintenance of clinical response compared with placebo (low certainty).

1 finding from 1 review

Budesonide vs placebo

Maintenance of histological response · Patients with collagenous colitis

It is very uncertain whether budesonide changes maintenance of histological response compared with placebo (very low certainty).

1 finding from 1 review

Budesonide vs placebo

Withdrawals due to adverse events · Patients with collagenous colitis

It is very uncertain whether budesonide changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Budesonide vs placebo

Serious adverse events · Patients with collagenous colitis

It is very uncertain whether budesonide changes serious adverse events compared with placebo (very low certainty).

1 finding from 1 review