Polyhexamethylene biguanide (PHMB) vs Normal saline
Change in ulcer size · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
3,971 questions · 9,849 findings · 853 reviews
No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%
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Polyhexamethylene biguanide (PHMB) vs Normal saline
Pain · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Polyhexamethylene biguanide (PHMB) vs Normal saline
Costs · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Polyhexamethylene biguanide (PHMB) vs Normal saline
Health related quality of life · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Polyhexamethylene biguanide (PHMB) vs Normal saline
Adverse events · people with venous leg ulcers
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Metronidazole gel 25% (local antibiotic) vs Placebo gel
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Metronidazole gel (25%, intrasocket) showed no clear difference in presence of dry socket compared with placebo gel; GRADE not reported.
1 finding from 1 review
- Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomesFollow-up: median 7 daysRR 0.53 [0.23, 1.20]1 study · 302 participantsGRADE not reported
Hall technique vs Compomer restoration or non-restorative caries treatment
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; the review reports this three-arm comparison but tabulates only compomer failure.
1 finding from 1 review
- Clinical effectiveness of restorative materials for the restoration of carious primary teeth without pulp therapy: a… 2022 All outcomes2.5 years · University · Class IIAnnual failure rate (%) PMC Hall technique 3.1%; compomer 14.7%1 study · 169 participantsGRADE not reported
Hall technique vs Conventional restoration
Discomfort during treatment · Children (3-10 years) with dentine caries in primary molars
The reported estimate for treatment discomfort with the Hall Technique versus conventional restorations was inconclusive (ungraded).
1 finding from 1 review
- Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review. 2022 All outcomesDuring treatmentRR 1.67 [0.65, 4.25]2 studiesGRADE not reported
Hall technique vs Conventional restoration
Adverse events: gingival bleeding · Children (3-10 years) with dentine caries in primary molars
The reported estimate for gingival bleeding with preformed metal crowns was inconclusive (ungraded).
1 finding from 1 review
- Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review. 2022 All outcomesNot reportedRR 1.09 [0.42, 2.86]2 studiesGRADE not reported
Hall technique vs Conventional restoration
Restoration failure · Children (3-10 years) with dentine caries in primary molars
The Hall Technique was reported to reduce restoration and major failure versus conventional restorations (3% vs 37%; ungraded).
1 finding from 1 review
- Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review. 2022 All outcomes1-5 years3% (HT) vs 37% (control)1 studyGRADE not reported
Dexamethasone mouthwash plus nystatin vs Photodynamic therapy
Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review
- Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomesBakhtiari 2017 (dexamethasone mouthwash + nystatin vs photodynamic therapy): clinical resolution reported (Analysis 4.6); no clear difference (low to very low certainty collectively)1 studyGRADE not reported
Intralesional dexamethasone injections vs placebo injection
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether intralesional dexamethasone injections changes maximal mouth opening (interincisal distance) compared with placebo injections (very low certainty).
2 findings from 1 review
- MD -2.10 [-6.77, 2.57]1 study · 25 participantsVery low
- MD -1.80 [-6.30, 2.70]1 study · 25 participantsVery low
Intralesional dexamethasone injections vs placebo injection
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether intralesional dexamethasone injections changes burning sensation (VAS 0-100) compared with placebo injections (very low certainty).
2 findings from 1 review
- MD -52.00 [-62.04, -41.96]1 study · 25 participantsVery low
- MD -46.00 [-53.44, -38.56]1 study · 25 participantsVery low
Intralesional dexamethasone injections vs placebo injection
Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
- Adverse effects (any): no adverse effects reported; 25 (1); no GRADE rating.1 study · 25 participantsGRADE not reported
Lycopene plus intralesional betamethasone vs placebo
Severity of oral/mucosal burning pain/sensation · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
- Kumar 2007 reported burning sensation using a non-validated scale; not included in quantitative analysis.1 studyGRADE not reported
Lycopene plus intralesional betamethasone vs placebo
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
- Kumar 2007 (3-arm: lycopene vs lycopene+intralesional betamethasone vs placebo): appeared to show increased interincisal distance in the two active groups, but limited withdrawal information/incomplete data meant…1 studyGRADE not reported
Intravitreal dexamethasone implant 0.7 mg vs sham
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · macular edema in diabetes
1 finding from 1 review
- no estimate extracted1 study · 701 participantsModerate
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Cataract progression · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher cataract progression ‐ 12 to 24 months compared with intravitreal antiVEGF (moderate certainty).
1 finding from 1 review
- RR 4.23 [2.36, 7.59]Studies not reportedModerate
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Use of IOP‐lowering medications ‐ 24 months · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher use of IOP‐lowering medications ‐ 24 months compared with intravitreal antiVEGF (moderate certainty).
1 finding from 1 review
- RR 4.76 [2.84, 7.99]Studies not reportedModerate
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Surgery for glaucoma ‐ 24 months · macular edema in diabetes
It is very uncertain whether intravitreal dexamethasone implant 0.7 mg changes surgery for glaucoma ‐ 24 months compared with intravitreal antiVEGF (very low certainty).
1 finding from 1 review
- RR 3.02 [0.12, 73.56]Studies not reportedVery low