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What do systematic reviews say?

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Evidence found and GRADE certainty

778 questions · 809 findings · 116 reviews

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No studies found 205 · 25.3%GRADE not reported 111 · 13.7%Very low 225 · 27.8%Low 155 · 19.2%Moderate 85 · 10.5%High 28 · 3.5%

Surgical vs non‐surgical treatment

Patient‐reported knee instabilitya Incidence of patellar subluxation · people with lateral patellar dislocation

It is very uncertain whether surgical changes patient‐reported knee instabilitya Incidence of patellar subluxation compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Surgical vs non‐surgical treatment

Subsequent requirement for surgery (re‐operations) for complications Incidence · people with lateral patellar dislocation

It is very uncertain whether surgical changes subsequent requirement for surgery (reoperations) for complicationsa… compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Low‐intensity pulsed ultrasound vs control

Delayed or non‐union (medium term) · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid,…

Low‐intensity pulsed ultrasound showed no clear difference in delayed or non‐union (medium term) compared with control (moderate certainty).

1 finding from 1 review

Low‐intensity pulsed ultrasound vs control

Adverse events ‐ total of adverse events (Skin irritation) · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid,…

It is very uncertain whether low‐intensity pulsed ultrasound changes adverse events Reported as skin irritation compared with control (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes hearing ‐ return to normal hearing Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes presence/persistence of OME Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Adverse event: persistent perforation · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes adverse event: persistent perforation compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Live birth rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

The review found no eligible studies for this question.

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

Starting administration of the progestogen earlier probably leads to higher clinical pregnancy rate compared with starting administration of the progestogen later (moderate certainty).

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Miscarriage · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

It is very uncertain whether starting administration of the progestogen earlier changes miscarriage Rate compared with starting administration of the progestogen later (very low certainty).

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Cycle cancellation rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

Starting administration of the progestogen earlier probably leads to lower cycle cancellation rate compared with starting administration of the progestogen later (moderate certainty).

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Endometrial thickness (mm) · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

The review found no eligible studies for this question.

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Other adverse effects · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

The review found no eligible studies for this question.

1 finding from 1 review