Incidence of bleedingd (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay
It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of bleedinge (early postoperative period) compared with pharmacological prophylaxis alone (very low certainty).
1 finding from 1 review
Incidence of major bleedingg (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay
It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of major bleedingg (early postoperative period) compared with pharmacological prophylaxis alone (very low certainty).
1 finding from 1 review
Exacerbation frequency · people with bronchiectasis
14 days on/off antibiotic regimen probably leads to lower exacerbation frequency compared with 14 days on/off placebo regimen (moderate certainty).
2 findings from 1 review
RR 0.75 [0.61, 0.93]
Studies not reported
Moderate
no estimate extracted
Studies not reported
Moderate
Serious adverse events · people with bronchiectasis
28 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 28 days on/off placebo regimen (low certainty).
1 finding from 1 review
OR 1 [0.68, 1.46]
Studies not reported
Low
Antibiotic resistance · people with bronchiectasis
28 days on/off antibiotic regimen leads to higher antibiotic resistance compared with 28 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 2.2 [1.42, 3.42]
Studies not reported
High
Pulmonary exacerbations: number of hospitalisations due to respiratory exacerbations · people with bronchiectasis
28 days on/off antibiotic regimen showed no clear difference in hospitalisation for pulmonary exacerbations compared with 28 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 0.79 [0.49, 1.29]
Studies not reported
High
Health‐related quality of life · people with bronchiectasis
2 findings from 1 review
no estimate extracted
Studies not reported
Moderate
no estimate extracted
Studies not reported
Low
Exacerbation frequency · people with bronchiectasis
14 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off antibiotic regimen (moderate certainty).
2 findings from 1 review
RR 1.02 [0.84, 1.24]
Studies not reported
Moderate
no estimate extracted
Studies not reported
No studies found
Serious adverse events · people with bronchiectasis
14 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 28 days on/off antibiotic regimen (moderate certainty).
1 finding from 1 review
OR 0.83 [0.37, 1.86]
Studies not reported
Moderate
Antibiotic resistance · people with bronchiectasis
14 days on/off antibiotic regimen showed no clear difference in antibiotic resistance compared with 28 days on/off antibiotic regimen (moderate certainty).
1 finding from 1 review
OR 1 [0.68, 1.48]
Studies not reported
Moderate
Frequency of hospital admissions for pulmonary exacerbations ‐ not measured · people with bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · people with bronchiectasis
2 findings from 1 review
no estimate extracted
Studies not reported
High
no estimate extracted
Studies not reported
High
Serious adverse events · people with bronchiectasis
14 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 14 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 0.92 [0.63, 1.33]
Studies not reported
High
Antibiotic resistance · people with bronchiectasis
14 days on/off antibiotic regimen leads to higher antibiotic resistance compared with 14 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 2.14 [1.36, 3.35]
Studies not reported
High
Frequency of hospital admissions for pulmonary exacerbations ‐ not measured · people with bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · people with bronchiectasis
2 findings from 1 review
no estimate extracted
Studies not reported
High
no estimate extracted
Studies not reported
Moderate
Exacerbation frequency · people with bronchiectasis
28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).
2 findings from 1 review
RR 0.92 [0.82, 1.02]
Studies not reported
High
no estimate extracted
Studies not reported
Low
Number of participants with symptomatic UTI · long‐term bladder management
Aseptic technique showed no clear difference in number with symptomatic UTI compared with clean technique (low certainty).
1 finding from 1 review
Cost‐effectiveness · long‐term bladder management
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Number of participants with symptomatic UTI · long‐term bladder management
Hydrophilic‐coated catheter showed no clear difference in number with symptomatic UTI compared with uncoated catheter (low certainty).
1 finding from 1 review