Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 487 findings · 44 reviews · Headline outcomes only

No studies found 117 · 24%GRADE not reported 31 · 6.4%Very low 131 · 26.9%Low 133 · 27.3%Moderate 61 · 12.5%High 14 · 2.9%

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

ALT >3 times the upper normal limit · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in ALT >3 times the upper normal limit at the end of compared with vitamin K antagonists (low certainty).

1 finding from 1 review