Intervention not reported
Adverse effects · Subfertile women
1 finding from 1 review
- no estimate extracted5 participantsGRADE not reported
Findings
What do systematic reviews say?
465 questions · 491 findings · 45 reviews
No studies found 117 · 23.8%GRADE not reported 35 · 7.1%Very low 131 · 26.7%Low 133 · 27.1%Moderate 61 · 12.4%High 14 · 2.9%
Direct thrombin inhibitors vs vitamin K antagonist (VKA)
Major VTE events in TKR combined doses bilateral ascending venography · patients with prevention of venous thromboembolism following total hip or knee replacement
Direct thrombin inhibitors showed no clear difference in major VTE events in TKR combined doses bilateral ascending venography compared with vitamin K antagonists (low certainty).
1 finding from 1 review
- Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes onlyOR 0.85 [0.63, 1.15]3 studies · 4327 participantsLow
Direct thrombin inhibitors vs vitamin K antagonist (VKA)
All‐cause Mortality events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement
Direct thrombin inhibitors showed no clear difference in all‐cause Mortality events in TKR combined doses compared with vitamin K antagonists (low certainty).
1 finding from 1 review
- Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes onlyOR 1.62 [0.57, 4.58]3 studies · 5243 participantsLow
Direct thrombin inhibitors vs vitamin K antagonist (VKA)
Total Bleeding events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement
Direct thrombin inhibitors showed no clear difference in total Bleeding events in TKR combined doses compared with vitamin K antagonists (low certainty).
1 finding from 1 review
- Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes onlyOR 1.26 [0.97, 1.62]3 studies · 5259 participantsLow
Direct thrombin inhibitors vs vitamin K antagonist (VKA)
ALT >3 times the upper normal limit · patients with prevention of venous thromboembolism following total hip or knee replacement
Direct thrombin inhibitors showed no clear difference in ALT >3 times the upper normal limit at the end of compared with vitamin K antagonists (low certainty).
1 finding from 1 review
- Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes onlyOR 5.61 [1, 31.64]2 studies · 4267 participantsLow