Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings for selective ß2‐adrenergic agonist vs no tocolytic agent, whilst awaiting emergency delivery

Perinatal death or severe morbidity · women with fetal distress for whom the decision had been made to delivery by emergency caesarean section

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Caesarean section · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate probably leads to higher caesarean delivery compared with emergency delivery (moderate certainty).

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Apgar score less than 7 at 5 minutes · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate showed no clear difference in 5‐minute Apgar score < 7 compared with emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Umbilical artery pH < 7.1 · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate showed no clear difference in umbilical artery pH < 7.1 compared with emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Perinatal death or severe morbidity · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

The review found no eligible studies for this question.

1 finding from 1 review