Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

781 questions · 1,089 findings · 92 reviews · Dental caries

No studies found 77 · 7.1%GRADE not reported 781 · 71.7%Very low 86 · 7.9%Low 97 · 8.9%Moderate 38 · 3.5%High 10 · 0.9%

Direct composite resin restoration vs Amalgam restoration

Allergic reaction · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride-releasing resin-based sealant vs Non-fluoride resin-based sealant

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

For resin-based sealants, fluoride release did not significantly change WSL initiation (RR 0.71, wide CI); subgroup not separately GRADE-rated.

1 finding from 1 review

Direct composite resin restoration vs Amalgam restoration

Fracture of restorations · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)

Direct composite resin restoration showed no clear difference in fracture of restorations compared with amalgam restoration (low certainty).

1 finding from 1 review

Coating material (bonding material or sealant) WITH fluoride release vs Coating material WITHOUT fluoride release

White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

White spot lesions were also measured by laser fluorescence in 3 fluoride-vs-non-fluoride studies, but no meta-analysis was possible due to incompatible reporting.

1 finding from 1 review

Direct composite resin restoration vs Amalgam restoration

Harms: injury · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)

The review found no eligible studies for this question.

1 finding from 1 review

Coating material (bonding material or sealant) WITH fluoride release vs Coating material WITHOUT fluoride release

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

Fluoride-releasing coating materials do not appear to reduce WSL initiation more than non-fluoride coatings (RR 0.84, not significant); certainty of evidence is very low.

1 finding from 1 review