Findings

What do systematic reviews say?

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Neurological function improvement: higher‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1480(4 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules showed no clear difference in neurological function improvement: higher‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
OR 1.14 [0.92, 1.42]
Studies not reported
Moderate

WBRT with radiosensitisers (radiosen) vs WBRT

Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases

WBRT with radiosensitisers (radiosen) showed no clear difference in overall survivalNo. of participants: 2631(8 RCTs) compared with WBRT alone (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
HR 1.05 [0.99, 1.12]
Studies not reported
Moderate

Intervention not reported

Depressive symptoms at end of treatment Beck Depression Inventory (BDI) or Hamilton Depression Rating Scale (HDRS). BDI is a self‐report inventory including 21 questions, each answer being scored from 0 to 3 with the total score ranging from 0 to ... · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 304 participants
Low

Intervention not reported

Persistence of depression at the end of treatment Beck Depression Inventory (BDI) or Hamilton Depression Rating Scale (HDRS) · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

It is very uncertain whether the intervention changes persistence of depression at the end of treatment Beck Depression… (very low certainty).

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
RR 0.48 [0.32, 0.7]
2 studies · 65 participants
Very low

Intervention not reported

Dropouts · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

The review found no eligible studies for this question.

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Relationship distress at the end of treatment Dyadic Adjustment Scale (DAS) or Maudsley Marital Questionnaire (MMQ). DAS is a self‐report inventory with 32 items, with the total score ranging from 0 to 151. Higher scores indicate less distress. MM... · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 60 participants
Very low

Intervention not reported

Depressive symptoms at the end of treatment Beck Depression Inventory (BDI) or Hamilton Depression Rating Scale (HDRS). BDI is a self‐report inventory including 21 questions, each answer being scored from 0 to 3 with the total score ranging from 0... · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Very low

Intervention not reported

Persistence of depression at the end of treatment · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

The review found no eligible studies for this question.

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Dropouts · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

It is very uncertain whether the intervention changes dropouts (very low certainty).

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
RR 1.03 [0.07, 15.52]
2 studies · 45 participants
Very low

Intervention not reported

Relationship distress at the end of treatment Dyadic Adjustment Scale (DAS) or Quality of Marriage Index ‐ QMI. DAS is a self‐report inventory with 32 items, with the total score ranging from 0 to 151. Higher scores indicate less distress. QMI is ... · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Very low

Intervention not reported

Persistence of depression at end of treatment Beck Depression Inventory (BDI) or Hamilton Depression Rating Scale (HDRS) · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

The intervention showed no clear difference in persistence of depression at end of treatment Beck Depression… (low certainty).

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
RR 0.94 [0.72, 1.22]
6 studies · 237 participants
Low

Intervention not reported

Dropouts · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

The intervention showed no clear difference in dropouts (low certainty).

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
RR 0.85 [0.51, 1.41]
9 studies · 364 participants
Low

Intervention not reported

Relationship distress at end of treatment Dyadic Adjustment Scale (DAS) or Maudsley Marital Questionnaire (MMQ). DAS is a self‐report inventory with 32 items, with the total score ranging from 0 to 151. Higher scores indicate less distress. MMQ is... · heterosexual adult couples aged > 18 with a partner having a clinical diagnosis of depressive disorder

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 187 participants
Very low

Intervention not reported

Depressive symptoms at end of treatment Beck Depression Inventory (BDI) or Hamilton Depression Rating Scale (HDRS). BDI is a self‐report inventory including 21 questions, each answer being scored from 0 to 3 with the total score ranging from 0 to ... · heterosexual adult couples aged >18 with a partner having a clinical diagnosis of depressive disorder

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Intervention not reported

Persistence of depression at end of treatment · heterosexual adult couples aged >18 with a partner having a clinical diagnosis of depressive disorder

The review found no eligible studies for this question.

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Dropouts · heterosexual adult couples aged >18 with a partner having a clinical diagnosis of depressive disorder

It is very uncertain whether the intervention changes dropouts (very low certainty).

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
RR 0.31 [0.15, 0.61]
2 studies · 95 participants
Very low

Intervention not reported

Relationship distress at post‐treatment Dyadic Adjustment Scale (DAS) or Maudsley Marital Questionnaire (MMQ). DAS is a self‐report inventory with 32 items, with the total score ranging from 0 to 151. Higher scores indicate less distress. MMQ is a... · heterosexual adult couples aged >18 with a partner having a clinical diagnosis of depressive disorder

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Intervention not reported

1 finding from 1 review

Couple therapy for depression 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 90 participants
Very low

Hyperbaric oxygen vs air breathing

Mortality with urinary bladder cancer · People with any one of a mixed group of cancers

Hyperbaric oxygen showed no clear difference in mortality with urinary bladder cancer compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 0.97 [0.74, 1.27]
4 studies · 330 participants
High

Hyperbaric oxygen vs air breathing

Failure of local tumour control ‐ not reported · People with any one of a mixed group of cancers

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found