Findings
What do systematic reviews say?
4,710 questions · 14,842 findings · 1,394 reviews
No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%
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Seizure recurrence at 1 year after randomisation · patients with first unprovoked seizure
Immediate treatment leads to lower seizure recurrence at 1 year after randomisation compared with controls (high certainty).
1 finding from 1 review
Mortality at the end of the · patients with first unprovoked seizure
Immediate treatment showed no clear difference in mortality at the end of the compared with controls (high certainty).
1 finding from 1 review
Adverse events (control ‐ deferred treatment) · patients with first unprovoked seizure
Immediate treatment probably leads to higher adverse events (control ‐ deferred treatment) compared with controls (moderate certainty).
1 finding from 1 review
Adverse events (control ‐ no treatment) · patients with first unprovoked seizure
Immediate treatment may leads to higher adverse events (control ‐ no treatment) compared with controls (low certainty).
1 finding from 1 review
Intervention not reported
Change from baseline in blood eosinophils (cells x 10*9/L) · children and adults with asthma
1 finding from 1 review
Intervention not reported
Change from baseline in Periostin (ng/mL) · children and adults with asthma
1 finding from 1 review
Intervention not reported
Percentage reduction from baseline in maintenance OCS dose · children and adults with asthma
1 finding from 1 review
Intervention not reported
Post hoc exploratory endpoint: Exacerbation requiring hospitalisation/ED/OCS (rate ratio) · children and adults with asthma
The intervention may leads to lower post hoc exploratory endpoint: Exacerbation requiring… (low certainty).
1 finding from 1 review
Intervention not reported
Change from baseline in pre‐bronchodilator FEV1 · children and adults with asthma
1 finding from 1 review
Intervention not reported
Change from baseline in FENO (ppb) · children and adults with asthma
1 finding from 1 review