Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,720 questions · 15,377 findings · 900 reviews

No studies found 3,865 · 25.1%GRADE not reported 2,291 · 14.9%Very low 3,875 · 25.2%Low 3,287 · 21.4%Moderate 1,681 · 10.9%High 378 · 2.5%

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Antioxidants vs placebo

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Antioxidant showed no clear difference in global impression of deterioration (investigator defined global… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Number of participants with gadolinium‐enhancing T1 lesions on MRI · people with multiple sclerosis

It is very uncertain whether antioxidant changes MRI activity(assessed as number of participants with… compared with placebo (very low certainty).

1 finding from 1 review

PUFA vs monounsaturated fatty acid (MUFA)

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Polyunsaturated fatty acid (PUFA) showed no clear difference in global impression of deterioration (investigator defined global… compared with monounsaturated fatty acid (MUFA) (low certainty).

1 finding from 1 review