SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
It is very uncertain whether hydroxyurea changes SCD‐related SAEs ‐ pain crisis compared with RBC transfusions (very low certainty).
1 finding from 1 review
Stroke · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
1 finding from 1 review
SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).
1 finding from 1 review
Cognitive function ‐ not reported · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not reported · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes proportion of participants developing new or progressive SCI lesions compared with RBC transfusion (very low certainty).
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes all‐cause mortality compared with RBC transfusion (very low certainty).
1 finding from 1 review
SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes SCD‐related SAEs ‐ ACS compared with RBC transfusion (very low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who had a stroke (secondary prevention)
Hydroxyurea may leads to higher SCD‐related SAEs ‐ pain crisis compared with RBC transfusion (low certainty).
1 finding from 1 review
Stroke · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes clinical stroke compared with RBC transfusion (very low certainty).
1 finding from 1 review
Cognitive function ‐ not reported · prevention of SCI in people with SCD who had a stroke (secondary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not reported · prevention of SCI in people with SCD who had a stroke (secondary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion may leads to lower SCD‐related SAEs ‐ pain crisis compared with standard care (low certainty).
1 finding from 1 review
Stroke · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion showed no clear difference in clinical stroke compared with standard care (low certainty).
1 finding from 1 review
Cognitive function · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
Quality of life · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and abnormal TCD velocities
Long‐term RBC transfusion may leads to lower proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD and abnormal TCD velocities
1 finding from 1 review
Intervention not reported
Medication‐taking ability · older patients using at least 4 regular prescription medications (and/or their carers)
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
Health‐related quality of life · older patients using at least 4 regular prescription medications (and/or their carers)
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate