Quality of life measures · children with SCD
1 finding from 1 review
Number of sickle cells, peripheral erythroblasts and reticulocytes · children with SCD
1 finding from 1 review
Frequency of hospital admissions from severe complications of SCD · people with SCD
1 finding from 1 review
no estimate extracted
70 participants
Low
Any adverse events including hepatic and renal toxicity · people with SCD
1 finding from 1 review
no estimate extracted
80 participants
Low
Frequency of blood transfusion · people with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in haemoglobin level from baseline · people with SCD
1 finding from 1 review
no estimate extracted
52 participants
Low
Quality of life measures: self reported health, absence from work or school · people with SCD
1 finding from 1 review
no estimate extracted
70 participants
Very low
Frequency, severity or duration of painful crises · people with SCD
1 finding from 1 review
Frequency of severe complications of SCD · people with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Perinatal mortality · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids leads to lower perinatal death (composite of fetal death (in utero death) and… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.85 [0.77, 0.93]
Studies not reported
High
Neonatal death (baby born alive at any gestation and dies within 28 days) · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids leads to lower neonatal death (infants born with signs of life who die within the… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.78 [0.7, 0.87]
Studies not reported
High
Respiratory distress syndrome · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids leads to lower respiratory distress syndrome№ of participants: 11,183(26 RCTs) compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.71 [0.65, 0.78]
Studies not reported
High
Intraventricular haemorrhage · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids probably leads to lower intraventricular haemorrhage (IVH)№ of participants: 8475(12 RCTs) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.58 [0.45, 0.75]
Studies not reported
Moderate
Mean birthweight · infants born of women at risk of preterm birth
1 finding from 1 review
no estimate extracted
Studies not reported
High
Developmental delay in childhood№ of participants: 600 (3 RCTs). Age at · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids probably leads to lower developmental delay in childhood№ of participants: 600 (3 RCTs). Age… compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.51 [0.27, 0.97]
Studies not reported
Moderate
Maternal death · women at risk of preterm birth
Maternal outcomes: corticosteroids showed no clear difference in maternal death compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 1.19 [0.36, 3.89]
Studies not reported
Moderate
Chorioamnionitis · women at risk of preterm birth
Maternal outcomes: corticosteroids showed no clear difference in chorioamnionitis№ of participants: 8374(15 RCTs) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.86 [0.69, 1.08]
Studies not reported
Moderate
Endometritis · women at risk of preterm birth
Maternal outcomes: corticosteroids showed no clear difference in endometritis№ of participants: 6764(10 RCTs) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 1.14 [0.82, 1.58]
Studies not reported
Moderate
Fever ‐ not measured · Women undergoing operative vaginal delivery
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Length of maternal hospital stay (days) · Women undergoing operative vaginal delivery
1 finding from 1 review
no estimate extracted
Studies not reported
Low