Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF
Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).
1 finding from 1 review
QoL · children, adolescents or adults with CF
Summary of findings: psychological interventions may leads to higher qoL CFQ‐R (Quittner 2009) compared with usual care (low certainty).
1 finding from 1 review
FEV1 % predicted · children, adolescents or adults with CF
Summary of findings: psychological interventions showed no clear difference in lung function FEV1 % predicted compared with usual care (moderate certainty).
1 finding from 1 review
Pulmonary exacerbations · children, adolescents or adults with CF
1 finding from 1 review
Adherence to inhaled therapies cMPR · adults (aged 16 years and over) with CF
1 finding from 1 review
Anxiety (adverse effect, post‐intervention) · adults (aged 16 years and over) with CF
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment‐related adverse events Depression · adults (aged 16 years and over) with CF
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality · adults and children with sickle cell disease and an increased risk of stroke
Summary of findings ‐ Hydroxyurea and phlebotomy showed no clear difference in death during the study (all deaths) compared with transfusion and chelation (low certainty).
1 finding from 1 review
Measures of HbF · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
Measures of ANC · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
Quality of life · adults and children with sickle cell disease and an increased risk of stroke
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events or toxicity: differences in rates of specific adverse events · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
Pain alteration: proportion experiencing serious VOC or sickle‐related pain events · adults and children with sickle cell disease and an increased risk of stroke
Summary of findings ‐ Hydroxyurea and phlebotomy may leads to higher pain alteration: proportion experiencing serious VOC or… compared with transfusion and chelation (low certainty).
1 finding from 1 review
Life‐threatening illness · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
Change in height · children with X‐linked hypophosphataemia
Summary of findings ‐ recombinant growth hormone showed no clear difference in longitudinal growth: change in height SDS compared with placebo or no intervention (low certainty).
1 finding from 1 review
Measures of mineral metabolism: change in serum phosphate mmol/L · children with X‐linked hypophosphataemia
It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of mineral metabolism: change in serum phosphate mmol/L compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Alkaline phosphatase · children with X‐linked hypophosphataemia
1 finding from 1 review
Measures of renal function: change in TmP/GFR · children with X‐linked hypophosphataemia
It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of renal function: change in TmP/GFR compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Body proportions: sitting height SDS · children with X‐linked hypophosphataemia
Summary of findings ‐ recombinant growth hormone showed no clear difference in body proportions: sitting height SDS compared with placebo or no intervention (moderate certainty).
1 finding from 1 review
Adverse effects · children with X‐linked hypophosphataemia
1 finding from 1 review