Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Change in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder
Topiramate showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).
1 finding from 1 review
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
1 finding from 1 review
Recurrence · older people in remission from depression
Antidepressant medication may leads to lower recurrence at 12 months compared with placebo at 12 months' follow‐up (low certainty).
1 finding from 1 review
Overall drop‐out rates (excluding deaths) at 12 months · older people in remission from depression
Antidepressant medication showed no clear difference in overall drop‐out rates (excluding deaths) at 12 months compared with placebo at 12 months' follow‐up (low certainty).
1 finding from 1 review
Change in depressive symptoms · depression in adults
1 finding from 1 review
Change in depressive symptoms · depression in adults
1 finding from 1 review
Secondary outcome: acceptability of treatment · depression in adults
It is very uncertain whether S‐adenosyl methionine as adjunctive treatment changes acceptability Participants dropping out of treatment during the… compared with placebo (very low certainty).
1 finding from 1 review
Proportions of participants responding to treatment ≥ 50% reduction in depression score from baseline to end of treatment. A larger RR indicates greater response to treatment in the SAMe group · depression in adults
S‐adenosyl methionine as adjunctive treatment may leads to higher proportions of participants responding to treatment ≥ 50% reduction… compared with placebo (low certainty).
1 finding from 1 review
Depression remission · depression in adults
S‐adenosyl methionine as adjunctive treatment may leads to higher proportions of participants achieving remission depression rating… compared with placebo (low certainty).
1 finding from 1 review
Secondary outcome: acceptability of treatment · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with placebo (low certainty).
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants responding to treatment ≥ 50% reduction… compared with placebo (low certainty).
1 finding from 1 review
Depression remission · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants achieving remission Depression rating… compared with placebo (low certainty).
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment responseCGI‐I · people with anxiety and comorbid alcohol use disorders
It is very uncertain whether paroxetine changes treatment responseCGI‐I compared with placebo (very low certainty).
1 finding from 1 review