Intervention not reported
Decrease in heart rate · Adults with primary hypertension
1 finding from 1 review
Intervention not reported
Decrease in pulse pressure · Adults with primary hypertension
1 finding from 1 review
Intervention not reported
Withdrawal due to adverse effect · Adults with primary hypertension
1 finding from 1 review
Intervention not reported
Time to treatment withdrawal ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention may leads to higher time to treatment withdrawal ‐ all participants Range of (low certainty).
1 finding from 1 review
Intervention not reported
Time to first seizure ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to first seizure ‐ all participants Range of (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to first seizure ‐ stratified by epilepsy type ‐ Generalised seizures Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to first seizure ‐ stratified by epilepsy type ‐ Generalised… (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to first seizure ‐ stratified by epilepsy type ‐ Partial onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to first seizure ‐ stratified by epilepsy type ‐ Partial onset… (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to treatment withdrawal ‐ stratified by seizure type ‐ Generalised seizures Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention may leads to higher time to treatment withdrawal ‐ stratified by seizure type ‐… (low certainty).
1 finding from 1 review
Intervention not reported
Time to treatment withdrawal ‐ stratified by seizure type ‐ Partial onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention may leads to higher time to treatment withdrawal ‐ stratified by seizure type ‐ Partial… (low certainty).
1 finding from 1 review
Intervention not reported
Time to 12‐month remission ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 12‐month remission ‐ all participants Range of (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to 12‐month remission ‐ stratified by seizure type ‐ Generalised seizures Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 12‐month remission ‐ stratified by seizure type ‐… (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to 12‐month remission ‐ stratified by seizure type ‐ Partial Onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 12‐month remission ‐ stratified by seizure type ‐ Partial… (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to 6‐month remission ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 6‐month remission ‐ all participants Range of (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to 6‐month remission ‐ stratified by seizure type ‐ Generalised seizures Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 6‐month remission ‐ stratified by seizure type ‐ Generalised… (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to 6‐month remission ‐ stratified by seizure type ‐ Partial onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 6‐month remission ‐ stratified by seizure type ‐ Partial… (moderate certainty).
1 finding from 1 review
Intervention not reported
All‐cause mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus
The intervention showed no clear difference in all‐cause mortality a. Intervention vs placebo [30 weeks to 4.75… (low certainty).
1 finding from 1 review
Intervention not reported
Non‐fatal macrovascular outcomes 1. Composite a. Intervention vs metformin [1a. 6 months to 4 years] b. Intervention vs thiazolidinediones [1b. 52 weeks to 4 years] c. Intervention vs meglitinide [1c. 12 months to 15 months]2. Non‐fatal myocardial... · participants with type 2 diabetes mellitus
The intervention may leads to lower non‐fatal macrovascular outcomes 1. Composite a. Intervention vs… (low certainty).
1 finding from 1 review
RR 0.67 [0.48, 0.93]
1 study · 3 participants
Low
Intervention not reported
Microvascular outcomes · participants with type 2 diabetes mellitus
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Adverse events 1. All adverse events 2. Drop‐outs due to adverse events 3. Severe hypoglycaemia a. Intervention vs placebo [1a. 24 weeks] [2a. 24 weeks to 56 weeks] b. Intervention vs metformin [1b. 6 months to 4 years] [2b. 24 weeks to 4 years] [... · participants with type 2 diabetes mellitus
The intervention showed no clear difference in adverse events 1. All adverse events 2. Drop‐outs due to adverse… (low certainty).
1 finding from 1 review
RR 0.91 [0.51, 1.62]
1 study · 2 participants
Low
Intervention not reported
Cancer a. Intervention vs thiazolidinediones [52 weeks to 4 years] b. Intervention vs insulin [6 years to 10 years] · participants with type 2 diabetes mellitus
The intervention showed no clear difference in cancer a. Intervention vs thiazolidinediones [52 weeks to 4 years]… (low certainty).
1 finding from 1 review