Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

764 questions · 795 findings · 110 reviews

No studies found 202 · 25.4%GRADE not reported 100 · 12.6%Very low 225 · 28.3%Low 155 · 19.5%Moderate 85 · 10.7%High 28 · 3.5%

Started toothbrushing with fluoride toothpaste at or before 24 months (earlier start) vs Started after 24 months (later start)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

It is very uncertain whether started toothbrushing with fluoride toothpaste at or before 24… changes fluorosis (percentage prevalence in permanent teeth) compared with started after 24 months (later start) (very low certainty).

2 findings from 1 review

Started toothbrushing with fluoride toothpaste before 12 months (earlier start) vs Started after 12 months (later start)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

It is very uncertain whether started toothbrushing with fluoride toothpaste before 12 months… changes fluorosis (percentage prevalence in permanent teeth) compared with started after 12 months (later start) (very low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Death at 1 year · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) showed no clear difference in death at 1 year compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Complete or substantial improvement of condition · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) may leads to higher complete or substantial improvement of condition compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Visual disturbances · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) leads to higher visual disturbances compared with control without HBOT (high certainty).

1 finding from 1 review

Surgical vs non‐surgical treatment

Number of participants sustaining recurrent patellar dislocation · people with lateral patellar dislocation

It is very uncertain whether surgical changes number of participants sustaining recurrent patellar dislocationa compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Surgical vs non‐surgical treatment

Kujala patellofemoral disorders score Scale from: 0 to 100 (higher scores = better function) · people with lateral patellar dislocation

It is very uncertain whether surgical changes knee and physical functiona Measured using the Kujala patellofemoral… compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Surgical vs non‐surgical treatment

Adverse effects of treatment Overall incidence of complications · people with lateral patellar dislocation

It is very uncertain whether surgical changes adverse effects of treatment Overall incidence of complications compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Surgical vs non‐surgical treatment

Patient‐reported knee instabilitya Incidence of patellar subluxation · people with lateral patellar dislocation

It is very uncertain whether surgical changes patient‐reported knee instabilitya Incidence of patellar subluxation compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Surgical vs non‐surgical treatment

Subsequent requirement for surgery (re‐operations) for complications Incidence · people with lateral patellar dislocation

It is very uncertain whether surgical changes subsequent requirement for surgery (reoperations) for complicationsa… compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Low‐intensity pulsed ultrasound vs control

Delayed or non‐union (medium term) · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid,…

Low‐intensity pulsed ultrasound showed no clear difference in delayed or non‐union (medium term) compared with control (moderate certainty).

1 finding from 1 review

Low‐intensity pulsed ultrasound vs control

Adverse events ‐ total of adverse events (Skin irritation) · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid,…

It is very uncertain whether low‐intensity pulsed ultrasound changes adverse events Reported as skin irritation compared with control (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes hearing ‐ return to normal hearing Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review