Findings

What do systematic reviews say?

754 questions · 769 findings · 35 reviews · Kidney and Transplant

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No studies found 228 · 29.6%GRADE not reported 3 · 0.4%Very low 215 · 28%Low 245 · 31.9%Moderate 74 · 9.6%High 4 · 0.5%

Intervention not reported

L‐carnitine VAS (0 to 6 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Low

Intervention not reported

Zinc sulfate VAS (0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 76 participants
Moderate

Intervention not reported

Ergocalciferol 21 point scale · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Intervention not reported

Turmeric Duo score (5 to 40) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Moderate

Intervention not reported

Fumaria parviflora VAS (0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 63 participants
Low

Intervention not reported

High flux/permeability dialysis VAS (0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 202 participants
Low

Intervention not reported

HD with haemoperfusion VAS (0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 90 participants
Low

Intervention not reported

UV‐B Duo score, VAS, and %improvement · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 86 participants
Low

Intervention not reported

Thermal therapy VAS (0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Low

ACUTE: Serelaxin vs placebo

Death (any cause) · heart failure with chronic kidney disease

ACUTE: Serelaxin showed no clear difference in death (any cause) compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.59 [0.34, 1.02]
2 studies · 1395 participants
Low

CHRONIC: ACEi or ARB vs placebo

Death (any cause) ( · heart failure with chronic kidney disease

CHRONIC: ACEi or ARB showed no clear difference in death (any cause) ( compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.85 [0.7, 1.02]
4 studies · 5003 participants
Low

CHRONIC: ACEi or ARB vs placebo

All cardiovascular death · heart failure with chronic kidney disease

CHRONIC: ACEi or ARB showed no clear difference in cardiovascular death ( compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.81 [0.64, 1.01]
2 studies · 1368 participants
Low

CHRONIC: ACEi or ARB vs placebo

Hospitalisation (any cause) · heart failure with chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CHRONIC: ACEi or ARB vs placebo

Heart failure hospitalisation (RR) · heart failure with chronic kidney disease

It is very uncertain whether CHRONIC: ACEi or ARB changes heart failure hospitalisation ( compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.9 [0.43, 1.9]
2 studies · 1368 participants
Very low

CHRONIC: ACEi or ARB vs placebo

Worsening heart failure · heart failure with chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CHRONIC: ACEi or ARB vs placebo

Worsening kidney function · heart failure with chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CHRONIC: ACEi or ARB vs placebo

Hypotension (ARB; withdrawn from study) · heart failure with chronic kidney disease

It is very uncertain whether CHRONIC: ACEi or ARB changes hypotension (ARB; withdrawn from study) compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 2.6 [1.12, 6.07]
1 study · 332 participants
Very low

CHRONIC: ACEi or ARB vs placebo

Hyperkalaemia · heart failure with chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CHRONIC: ACEi or ARB vs placebo

Quality of life · heart failure with chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CHRONIC: Beta‐blockers vs placebo

Death (any cause) ( · heart failure with chronic kidney disease

CHRONIC: Beta‐blockers probably leads to lower death (any cause) ( compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.69 [0.6, 0.79]
4 studies · 3136 participants
Moderate